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Process Safety Specialist

2 months ago


Sandwich, Kent, United Kingdom Asymchem Group Full time
About Asymchem Group

Asymchem Group is a global integrated Contract Development and Manufacturing Organization (CDMO) providing drug R&D and manufacturing for leading pharmaceutical and biotech companies.

Job Overview

We are seeking a highly skilled Process Safety Specialist to join our team at our new Sandwich laboratories. As a key member of our collaborative team, you will play a pivotal role in ensuring the safety of processes intended for Manufacture of APIs, and their intermediates, on laboratory, pilot plant and commercial manufacturing scales.

Key Responsibilities
  • Process Safety Workflows: Apply Process Safety workflows in partnership with project teams during laboratory scale-up and scale-up into pilot plant facilities, ensuring appropriate recommendations are made.
  • Experimental Design: Design, execute and interpret complex laboratory experiments to accurately assess the safety of starting materials, intermediates, reagents waste streams and chemical reactions prior to scale-up and help implement suitable mitigation measures.
  • Recommendations and Reporting: Formulate clear, concise recommendations based on process safety testing results in detailed reports and oral representation.
  • Technology Evaluation: Lead / contribute to the evaluation of novel technologies and techniques to maintain world class process safety testing capabilities.
  • Laboratory Operations: Maintain laboratory operations, proactively work with vendors / internal engineers to maintain equipment to a high standard and ensure optimal performance to mitigate down time.
  • Process Safety Initiatives: Identify initiatives to enhance process safety workflows and technology to improve process safety testing efficiency.
  • Collaboration and Networking: Ensure good collaboration and proactive engagement with external bodies where necessary, to enhance knowledge within the group. Establish networks and interfaces across the pharma/CDMO space and academia.
  • Resource Planning: Collaborate with stakeholders to forecast short, mid and long term forecasts for resource needs to ensure customers needs are met.
  • Expert Opinion: Acts as a resource across the process safety network to give expert opinion and alternative insights on the interpretation of data to ensure effective assessment of chemical reaction hazards.
  • Training and Development: Deliver process safety testing training to new starters and develop new training materials where required as the process safety function evolves.
Requirements
  • Education and Experience: BS/MS in chemistry or chemical engineering with a minimum 5 years (relevant API) experience in small molecule development.
  • Process Safety Knowledge: Awareness and expertise in the various elements and concepts of process safety testing and inherently safer process design.
  • Equipment Operation: Hands-on experience operating and data interpretation from the following state of the art process safety testing equipment: Differential Scanning Calorimetry, Thermal Screening Unit (or similar), Accelerating Rate Calorimetry, Mettler Toledo RC1.
  • Documentation and Analysis: Experience in writing process safety testing documents to support the safe scale-up of processes during laboratory studies and tech transfer to pilot plant and commercial facilities. Active participant in process hazard analyses.
  • Mentorship and Leadership: Proven track record in mentoring junior colleagues.
  • Analytical and Problem-Solving Skills: Ability to perform complex tasks such as handling large amounts of data and performing mathematical calculations.