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Scientist: Manufacturing Process Safety
2 months ago
Asymchem Group is seeking a highly skilled Scientist: Manufacturing Process Safety to join our team in Sandwich, UK. As a key member of our process safety team, you will play a pivotal role in ensuring the safe scale-up of processes from laboratory to commercial manufacturing scales.
Key Responsibilities:- Apply process safety workflows in partnership with project teams during laboratory scale-up and scale-up into pilot plant facilities, ensuring appropriate recommendations are made.
- Design, execute and interpret complex laboratory experiments to accurately assess the safety of starting materials, intermediates, reagents waste streams and chemical reactions prior to scale-up and help implement suitable mitigation measures.
- Formulate clear, concise recommendations based on process safety testing results in detailed reports and oral representation.
- Lead/contribute to the evaluation of novel technologies and techniques to maintain world-class process safety testing capabilities.
- Maintain laboratory operations, proactively work with vendors/internal engineers to maintain equipment to a high standard and ensure optimal performance to mitigate downtime.
- Identify initiatives to enhance process safety workflows and technology to improve process safety testing efficiency.
- Establish networks and interfaces across the pharma/CDMO space and academia.
- Act as a resource across the process safety network to give expert opinion and alternative insights on the interpretation of data to ensure effective assessment of chemical reaction hazards.
- Work with external testing houses to identify and coordinate safety testing where required to generate data outside of internal capabilities and foster effective relationships.
- Deliver process safety testing training to new starters and develop new training materials where required as the process safety function evolves.
- BS/MS in chemistry or chemical engineering with a minimum 5 years (relevant API) experience in small molecule development.
- Awareness and expertise in the various elements and concepts of process safety testing and inherently safer process design.
- Hands-on experience operating and data interpretation from the following state-of-the-art process safety testing equipment: Differential Scanning Calorimetry, Thermal Screening Unit (or similar), Accelerating Rate Calorimetry, Mettler Toledo RC1.
- Experience in writing process safety testing documents to support the safe scale-up of processes during laboratory studies and tech transfer to pilot plant and commercial facilities.
- Active participant in process hazard analyses.
- Ability to perform complex tasks such as handling large amounts of data and performing mathematical calculations.
