Immunology Cancer Research Specialist

1 month ago


London, Greater London, United Kingdom UCL Eastman Dental Institute Full time
About the Role

We are seeking a talented and enthusiastic Post-Doctoral fellow to join our dynamic team in the Therapeutic vulnerabilities in solid tumors and sarcoma group of Dr Sophie Postel-Vinay, in collaboration with the Immune Regulation and Tumour Immunotherapy group from Sergio Quezada.

The applicant will have the opportunity to join a new group that is being developed in collaboration with an established dynamic team at UCL Eastman Dental Institute, and collaborators at Gustave Roussy, France. The exciting program aims at developing and evaluating novel therapeutic approaches to target aggressive transcription factors-driven sarcomas using neoantigen-based approaches (Vibert et al, Cell Rep ) and surface markers-based approaches.

The project focuses on functional immunology and surface markers, with the aim to ultimately develop a targeted therapeutic approach to be translated into the clinic. The successful candidate will work under the supervision of the PI in close collaboration with expert immunology teams involved in the project at UCL (Prof Sergio Quezada +/- Prof Kerry Chester), Gustave Roussy and Institut Curie (France; Dr Josh Waterfall).

Key Responsibilities
  • Conduct research in cancer biology, immunology, and molecular biology
  • Develop and evaluate novel therapeutic approaches to target aggressive transcription factors-driven sarcomas
  • Collaborate with expert immunology teams involved in the project

This position is funded for 3 years in the first instance with the possibility of extension. Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Grade 6B as Research Assistant with payment at Grade 7 being backdated to the date of final submission of the PhD Thesis.

Requirements

The successful candidate must have a PhD (or close to completion) with relevant laboratory experience or an MSc. in Cancer Biology, Immunology or a related discipline (or close to completion) or higher degree and ability to perform molecular and cellular biology, tissue culture, flow cytometry, cloning and in vitro cell-based experiments and to undergo further training if required.

The candidate should have a solid knowledge of immunology, proteomics, molecular and cellular biology (including genome editing by CRISPR and lentival transfections, molecular cloning, flow cytometry, immune and cancer cell culture tissue culture), and TCR or antibody-based therapy. This role will also benefit those who have experience in bioinformatics (notably proteomics, immunoproteomics and single-cell analysis) and mouse work.

Salary and Benefits

The salary for this position is around £40,000 - £50,000 per annum, depending on experience. We offer a range of benefits including:

  • 41 Days holiday (including 27 days annual leave, 8 bank holidays and 6 closure days)
  • Defined benefit career average revalued earnings pension scheme (CARE)
  • Cycle to work scheme and season ticket loan
  • On-Site nursery
  • On-site gym
  • Enhanced maternity, paternity and adoption pay
  • Employee assistance programme: Staff Support Service
  • Discounted medical insurance


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