Senior Research Scientist

1 week ago

Great Abington, United Kingdom Cancer Research UK Full time
About Cancer Research UK

Cancer Research UK is a world-leading charity dedicated to beating cancer through research and innovation. Our mission is to bring forward the day when all cancers are conquered.

Job Summary

We are seeking an Associate Scientist to join our antibody discovery team, where you will play a key role in delivering therapeutic antibodies against a range of oncology targets. As an Associate Scientist, you will work closely with a multi-disciplinary team to generate antibody and antibody fragment reagents, perform purification, and maintain inventory.

Key Responsibilities
  • Generate antibody and antibody fragment reagents using bacterial and mammalian expression systems
  • Perform purification of antibody and antigen proteins using AKTA and other automated purification platforms
  • QC antibodies using analytical techniques such as SDS-PAGE, HPLC, and Western blotting
  • Maintain inventory of antibody and antigen proteins and support supply of candidates to the wider Antibody Discovery and Bioscience team
  • Efficiently undertake molecular biology tasks such as restriction digest and golden gate cloning
  • Maintain and operate state-of-the-art laboratory equipment
Requirements
  • Degree in a relevant field
  • Knowledge of current protein expression and purification methods
  • Knowledge of biochemical and/or cell-based assay systems
  • Knowledge of current molecular biology techniques relevant to the construction of expression vectors for downstream screening of antibodies and antibody fragments
  • Experience in protein purification and use of AKTA instrumentation desired
  • Experience with mammalian transient expression desired
  • Knowledge of and interest in learning phage display technology and its application within antibody discovery programs
What We Offer

We offer a competitive salary and benefits package, as well as opportunities for career and personal development. Our organisation values are designed to guide all that we do, and we are looking for individuals who can embody these values and drive forward progress against our mission to beat cancer.

How to Apply

We operate an anonymised shortlisting process in our commitment to equality, diversity, and inclusion. CVs are required for all applications, but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.

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