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Senior Research Scientist

2 months ago

Great Abington, United Kingdom Cancer Research UK Full time
About Cancer Research UK

Cancer Research UK is a world-leading charity dedicated to beating cancer through research and innovation. Our mission is to bring forward the day when all cancers are conquered.

Job Summary

We are seeking an Associate Scientist to join our antibody discovery team, where you will play a key role in delivering therapeutic antibodies against a range of oncology targets. As an Associate Scientist, you will work closely with a multi-disciplinary team to generate antibody and antibody fragment reagents, perform purification, and maintain inventory.

Key Responsibilities
  • Generate antibody and antibody fragment reagents using bacterial and mammalian expression systems
  • Purify antibody and antigen proteins using AKTA and other automated purification platforms
  • Perform quality control using analytical techniques such as SDS-PAGE, HPLC, and Western blotting
  • Maintain inventory of antibody and antigen proteins and support supply to the wider Antibody Discovery and Bioscience team
  • Undertake molecular biology tasks such as restriction digest and golden gate cloning
  • Maintain and operate state-of-the-art laboratory equipment
Requirements
  • Relevant degree in a life science or related field
  • Knowledge of current protein expression and purification methods
  • Knowledge of biochemical and/or cell-based assay systems
  • Knowledge of molecular biology techniques relevant to the construction of expression vectors for downstream screening of antibodies and antibody fragments
  • Experience in protein purification and use of AKTA instrumentation (desired)
  • Experience with mammalian transient expression (desired)
  • Knowledge of and interest in learning phage display technology and its application within antibody discovery programs
What We Offer

We offer a competitive salary and benefits package, as well as opportunities for career development and personal growth. Our organisation values are designed to guide all that we do, and we are committed to creating a working environment that supports your wellbeing and promotes inclusivity and collaboration.

How to Apply

We operate an anonymised shortlisting process to ensure fairness and objectivity. Please submit your CV and complete the work history section of the online application form. We look forward to hearing from you.