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Scientist in Antibody Discovery

1 month ago

Great Abington, United Kingdom Cancer Research UK Full time

About the Role

We are seeking an ambitious and proactive scientist to join our antibody discovery team at Cancer Research UK. As an Associate Scientist, you will play a key role in delivering therapeutic antibodies against a range of oncology targets.

Key Responsibilities

  • Generate antibody and antibody fragment reagents for the laboratory using bacterial and mammalian expression systems
  • Perform purification of antibody and antigen proteins using AKTA and other automated purification platforms
  • QC antibodies using analytical techniques such as SDS-PAGE, HPLC and Western blotting
  • Maintain inventory of antibody and antigen proteins, support supply of candidates to wider Antibody Discovery and Bioscience team
  • Efficiently undertake molecular biology tasks such as restriction digest and golden gate cloning
  • Maintaining and operating state of the art laboratory equipment

Requirements

  • A Degree in relevant field
  • Knowledge of current protein expression and purification methods
  • Knowledge of biochemical and/or cell-based assay systems
  • Knowledge of current molecular biology techniques relevant to the construction of expression vectors for downstream screening of antibodies and antibody fragments
  • Experience in protein purification and use of AKTA instrumentation desired
  • Experience with mammalian transient expression desired
  • Knowledge of and interest in learning phage display technology and its application within antibody discovery programs

About Cancer Research UK

Cancer Research UK is the world's biggest medical research charity, and we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of world class biology, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.

What We Offer

We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.

How to Apply

We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.