Research and Development Biologist
1 week ago
Company Overview: Immunocore is a pioneering biotechnology company focused on developing transformative medicines addressing unmet patient needs. With a strong track record of innovation, we strive to create an environment where talented individuals can thrive.
\About the Role: We are seeking a Principal Research Scientist In Silico Biologics Design to join our Protein Engineering team. As a key member of our research group, you will drive the establishment of robust in silico methodologies to revolutionize the design of our T-cell receptor (TCR) drugs.
\Key Responsibilities:
\- \
- Develop and assess advanced machine learning models for novel antibody and TCR drug candidate optimization.\
- Utilize our extensive in-house structural and specificity data sets to extract further value.\
- Work with colleagues across Research to identify training data from the public domain and help shape the development of our in-house data sets.\
- Drive the establishment of virtual screening tools, including protein structure prediction, affinity prediction, peptide human leukocyte antigen (pHLA) specificity prediction, and developability prediction.\
- Assist with TCR library design for multifactorial lead optimization.\
- Work with interdisciplinary teams to integrate machine learning into TCR discovery and optimization.\
- Promote utilization of ML algorithms among colleagues and mentor/train others in their deployment.\
- Present research outcomes at all levels, including Protein Engineering lab meetings and external conferences.\
Requirements:
\- \
- Demonstrated ability to build and evaluate machine learning models.\
- At least 8 years of experience in antibody, TCR or biologics design, evidenced by a strong publication record.\
- Proficiency with protein ML models such as AlphaFold, ESMFold, RFdiffusion, MPNN.\
- Advanced Python programming skills, focusing on data science and machine learning.\
- Managed sizeable research projects, understanding the wider implications of project outcomes and strategic objectives.\
- Exceptional communication skills.\
- Demonstrated ability to build and sustain networks and external collaboration with scientific leaders in the field.\
- PhD in Computational Biology, Computational Chemistry, Bioinformatics, or related discipline.\
Estimated Salary Range: £120,000 - £180,000 per annum, depending on experience.
-
Research Biologist
2 weeks ago
Oxford, Oxfordshire, United Kingdom OBN Ltd Full timeWe are seeking a highly skilled Research Biologist to join our team at OMass Therapeutics in Oxford. As a Senior Scientist, you will play a key role in solving drug discovery challenges using your structural biology expertise and scientific curiosity.About the RoleThe successful candidate will work closely with our Protein Biochemistry & Structural Biology...
-
Senior Computational Biologist
1 week ago
Oxford, Oxfordshire, United Kingdom Vertex Pharmaceuticals Full timeVertex PharmaceuticalsAt Vertex, we're committed to solving the toughest challenges in medicine. As a Senior Computational Biologist, you'll play a key role in driving our mission forward. This is an on-site or hybrid eligible position based out of our site in Oxford, UK, requiring at least 3 days/week onsite.We're seeking a highly skilled computational...
-
AI Research Developer
2 weeks ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeResearch Software Engineer (Machine Learning)The University of Oxford is seeking a Senior Research Software Engineer based at the Department of Computer Science. This role is part of the NERC funded Morphocam project, which aims to develop machine learning/AI tools for precise metrics measurements on camera trap images of wild animals.As a Senior Research...
-
Senior Computational Biologist
2 weeks ago
Oxford, Oxfordshire, United Kingdom Hlx Life Sciences Full timeHlx Life Sciences is seeking a highly experienced Senior Computational Biologist to join our team. As a Senior Computational Biologist, you will be responsible for developing models for computational protein engineering and collaborating with data scientists, bioinformaticians, protein engineers, and molecular biologists to create and continuously improve...
-
Cancer Research Data Lead
2 weeks ago
Oxford, Oxfordshire, United Kingdom NHS Research and Development Forum Full timeDo you want to make a real difference in the field of cancer research? We have an exciting opportunity for a Cancer Research Data Lead to join our team at the NHS Research and Development Forum. This role will involve leading the development, integration, and maintenance of cancer data information systems to support clinical trials.The successful candidate...
-
Conservation Biologist
2 weeks ago
Oxford, Oxfordshire, United Kingdom Penguin Recruitment Full timeWe are recruiting for a Conservation Biologist to join our team in Oxford, providing an exciting opportunity for someone to make a real impact in the field of ecology.In this role, you will conduct Preliminary Ecological Appraisals and protected species surveys, collecting and analyzing data to inform your reports.Requirements for this position include...
-
Senior Molecular Biologist
5 days ago
Oxford, Oxfordshire, United Kingdom Theolytics Full timeAbout UsTheolytics is a pioneering biotechnology company dedicated to transforming patients' lives through innovative oncolytic viral therapies. Our mission is to provide better outcomes for patients with limited treatment options, particularly those suffering from ovarian cancer, colorectal cancer, and hematological malignancies.Job DescriptionWe are...
-
Computational Biologist for Immunotherapy
6 days ago
Oxford, Oxfordshire, United Kingdom Immunocore Full timeJob OverviewWe are seeking an experienced bioinformatician to work closely with Research and Bioinformatics/Data Science teams at Immunocore, a pioneering biotechnology company developing transformative medicines for oncology, infectious diseases, and autoimmune disease. The ideal candidate will be a driven, curious, and collaborative scientist passionate...
-
Computational Biologist
3 days ago
Oxford, Oxfordshire, United Kingdom Immunocore Full timeDrive Innovation in Biologics Drug Discovery as a Data AnalystWe are seeking an experienced Data Analyst to join our Protein Engineering department at Immunocore. As a key member of our team, you will work closely with experimental biologists to design and automate the capture, organisation, and analysis of experimental data for biologics drug...
-
Biologist Specialist
3 weeks ago
Oxford, Oxfordshire, United Kingdom Economicsnetwork Full timeAs a key member of the Economicsnetwork team, we are seeking a highly skilled Biologist Specialist to lead analysis of single-cell gene expression and open chromatin profiling data to investigate transcriptional regulation during Drosophila Melanogaster brain development.The successful candidate will work with experimental collaborators to answer questions...
-
Molecular Biologist
2 weeks ago
Oxford, Oxfordshire, United Kingdom Northreach Full timeCancer Immunotherapy Expert NeededWe are seeking a highly skilled Molecular Biologist to join our team, focused on developing novel cancer immunotherapies. As a key contributor, you will drive innovation and make a significant impact in the fight against cancer.About the PositionConduct experiments to generate and select yeast TCR display libraries,...
-
Computational Biologist
6 days ago
Oxford, Oxfordshire, United Kingdom Northreach Full timeJob Overview: We are seeking a highly skilled Computational Biologist to join our team. As a key member of our multidisciplinary scientific team, you will be responsible for conceptualising, designing, and implementing innovative data analysis strategies to advance our client's ERAP1 inhibitor-driven antigen discovery pipeline.Main Responsibilities-...
-
Senior Computational Biologist
7 days ago
Oxford, Oxfordshire, United Kingdom Immunocore Full timeRole and ResponsibilitiesAs a senior bioinformatician, you will work in interdisciplinary teams across protein engineering and bioinformatics to develop and integrate data science approaches into TCR and antibody discovery and optimisation. You will analyse, manage, and organise datasets generated across a protein engineering campaign, including...
-
Research Engineer for Computer Vision
2 weeks ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeAbout the RoleWe are hiring a Data Science and Engineering Specialist to join our research group at the Department of Computer Science, University of Oxford. The successful candidate will have expertise in developing and deploying machine learning models and frameworks to analyze camera trap images of wild animals.The role involves collaborating with field...
-
Oxford, Oxfordshire, United Kingdom CV-Library Full timeWe are seeking a highly skilled molecular biologist to join our team and drive product development within our diagnostic platforms. As a senior assay development specialist, you will be responsible for leading R&D projects and delivering project results through internal and external meetings.The ideal candidate will have commercial experience in assay design...
-
Conservation Biologist Role
1 week ago
Oxford, Oxfordshire, United Kingdom Access Talent Group Full timeKey Responsibilities:We are looking for a highly motivated and experienced Conservation Biologist to join our team at Access Talent Group near Oxford. As a Senior Ecologist, you will be responsible for managing projects and leading a team of junior staff.• You will manage project timelines and budgets to ensure successful project delivery.• You will line...
-
Bioinformatics Specialist
3 days ago
Oxford, Oxfordshire, United Kingdom Immunocore Full timeUnlock the Power of Genomics in ImmunotherapyWe are seeking a highly skilled Bioinformatics Specialist to join our Research and Development team at Immunocore, a pioneering biotechnology company. As a key member of our Protein Engineering department, you will work closely with experimental biologists to design and automate the capture, organisation, and...
-
Senior Research Biologist
2 days ago
Oxford, Oxfordshire, United Kingdom Immunocore Full timeCompany OverviewImmunocore is a pioneering biotechnology company that develops transformative medicines addressing unmet patient needs in oncology, infectious diseases, and autoimmune disease. Our leaders are renowned for their expertise in drug development, creating an innovative environment where scientists collaborate to answer pressing questions.We...
-
Research Software Development Specialist
2 weeks ago
Oxford, Oxfordshire, United Kingdom Society of Research Software Engineering Full timeJob OverviewThe Society of Research Software Engineering is looking for a highly skilled Research Software Development Specialist to join our team. This is an exciting opportunity to work on a diverse selection of world-leading and impactful projects, contributing to the creation, improvement, and maintenance of software used for scientific research and...
-
Senior Machine Learning Software Developer
2 weeks ago
Oxford, Oxfordshire, United Kingdom University of Oxford Full timeJob DescriptionWe are seeking a highly skilled Senior Machine Learning Software Developer to join our team at the Department of Computer Science, University of Oxford. As a key member of our research group, you will play a vital role in developing and implementing machine learning models and frameworks to enable precise metrics measurements on camera trap...