Research and Development Biologist

1 week ago


Oxford, Oxfordshire, United Kingdom Immunocore Full time

Company Overview: Immunocore is a pioneering biotechnology company focused on developing transformative medicines addressing unmet patient needs. With a strong track record of innovation, we strive to create an environment where talented individuals can thrive.

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About the Role: We are seeking a Principal Research Scientist In Silico Biologics Design to join our Protein Engineering team. As a key member of our research group, you will drive the establishment of robust in silico methodologies to revolutionize the design of our T-cell receptor (TCR) drugs.

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Key Responsibilities:

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  • Develop and assess advanced machine learning models for novel antibody and TCR drug candidate optimization.\
  • Utilize our extensive in-house structural and specificity data sets to extract further value.\
  • Work with colleagues across Research to identify training data from the public domain and help shape the development of our in-house data sets.\
  • Drive the establishment of virtual screening tools, including protein structure prediction, affinity prediction, peptide human leukocyte antigen (pHLA) specificity prediction, and developability prediction.\
  • Assist with TCR library design for multifactorial lead optimization.\
  • Work with interdisciplinary teams to integrate machine learning into TCR discovery and optimization.\
  • Promote utilization of ML algorithms among colleagues and mentor/train others in their deployment.\
  • Present research outcomes at all levels, including Protein Engineering lab meetings and external conferences.\
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Requirements:

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  • Demonstrated ability to build and evaluate machine learning models.\
  • At least 8 years of experience in antibody, TCR or biologics design, evidenced by a strong publication record.\
  • Proficiency with protein ML models such as AlphaFold, ESMFold, RFdiffusion, MPNN.\
  • Advanced Python programming skills, focusing on data science and machine learning.\
  • Managed sizeable research projects, understanding the wider implications of project outcomes and strategic objectives.\
  • Exceptional communication skills.\
  • Demonstrated ability to build and sustain networks and external collaboration with scientific leaders in the field.\
  • PhD in Computational Biology, Computational Chemistry, Bioinformatics, or related discipline.\
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Estimated Salary Range: £120,000 - £180,000 per annum, depending on experience.


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