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Director, Quantitative Biomarkers Specialist
2 months ago
Exscientia is a pioneering AI-driven precision medicine company dedicated to developing innovative treatments for complex diseases. Our cutting-edge platform enables the rapid discovery, design, and development of high-quality drugs, with a focus on oncology and other therapeutic areas.
The RoleWe are seeking a highly skilled Director, Quantitative Biomarkers to lead our preclinical and clinical translational research programs in oncology. As a key member of our team, you will be responsible for designing, implementing, and interpreting biomarker strategies to support early clinical programs. Your expertise will be crucial in defining pharmacodynamic markers to support proof of mechanism determination and informing indication and dosing regimen selection.
Key Responsibilities- Develop and deliver clinical biomarker strategies for preclinical and clinical assets, collaborating with cross-functional teams to drive project success.
- Analyze and interpret emerging clinical biomarker data, working closely with quantitative clinical pharmacology to support model-informed drug development.
- Contribute to building scientific rationale to support clinical strategy, exploring novel indications, targeted patient populations, and new drug combinations for compounds in research, preclinical, and clinical development.
- Regularly report biomarker data to project teams, line management, and senior governance groups.
- Fulfill regulatory responsibilities, including preparing, updating, and finalizing biomarker sections in clinical protocols, Investigator Brochures, Clinical Study Reports, and compound development plans.
- Contribute to preclinical experimental plan development, supervise studies, and integrate into clinical development plans.
- Establish and maintain collaborations with internal experts, external experts, academic groups, and CROs to drive project success.
- MSc, PhD, or PharmD in immuno-oncology, tumor biology, or a related field.
- 10+ years of experience in quantitative biomarker/translational biology research in a pharmaceutical/biotech setting, including 3+ years of clinical trial experience.
- Experience in designing and executing preclinical research, in-vitro and in-vivo pharmacology, and mechanism of action studies.
- Leadership experience in drug discovery/development, representing clinical BTB research on project teams and communicating goals and deliverables to senior management and governance committees.
- Ability to work effectively on multiple oncology programs in a fast-paced environment, with resilience and adaptability to changes in priorities.
- Strong collaboration and teamwork skills, with excellent written and verbal communication.
- A dynamic and inclusive work environment that values diversity, equity, and inclusion.
- Opportunities for professional growth and development, with access to training and mentorship programs.
- A competitive salary and benefits package, including comprehensive private health insurance, dental, and vision benefits.
- A generous holiday allowance and flexible working arrangements to support work-life balance.
- A comprehensive employee assistance program, including mental health support and access to therapy and counseling sessions.
- A pension and life cover scheme to support your financial well-being.
- A range of social events and activities to foster a sense of community and connection among team members.
