Research Associate

2 months ago


Hammersmith, United Kingdom Imperial College London Full time

Research in the Division of Neuroscience addresses mechanisms that underpin nervous system functions and diseases. Investigators in the Division are exploring these through combinations of neurophysiological, anatomical, molecular, cellular and computational approaches, using pre-clinical models and clinical studies.

The post is funded by funds to Di Giovanni’s lab to investigate the molecular and cellular underpinnings of regenerative failure after nerve and spinal cord injuries.

To carry out research programmes in molecular and cellular underpinnings of regenerative failure after nerve and spinal cord injuries. The Research Associate will be expected to generate data of high quality that can be submitted for publication to high-profile refereed journals and to attract external research funding.

Exciting recent research developments have placed the role of axonal signalling and transcriptional regulation at the centre of the capacity of axons to re-grow after spinal cord injury. These include work from our laboratory (see Di Giovanni S, on PubMed). Given that neurological recovery and axonal regeneration are not possible following a spinal injury, understanding how the re-growth of injured axons is controlled is key to enhancing axonal regeneration and potentially functional recovery. Axonal signalling and metabolic control seem important for modulating the complex gene expression program necessary for the regrowth of an axon. However, the role of environmental factors in signalling and metabolic pathways in axonal regeneration remains obscure.

**Duties and responsibilities**:

- To take initiatives in the planning of research
- To direct the work of small research teams
- To identify and develop suitable techniques, and apparatus, for the collection and analysis of data
- To conduct data analysis
- To ensure the validity and reliability of data at all times
- To maintain accurate and complete records of all findings
- To write reports for submission to research sponsors
- To present findings to colleagues and at conferences
- To submit publications to refereed journals

**Essential requirements**:

- **Research Associate**: Hold or be about to obtain a PhD in Neuroscience a closely related discipline, or equivalent research, industrial or commercial experience
- ** Research Assistant**: Near completion of a PhD in Neuroscience a closely related discipline, or equivalent research, industrial or commercial experience- Practical experience within a research environment and/or publication in relevant and refereed journals
- Practical experience in a broad range of techniques including in molecular and cellular biology, as well as in in vivo murine work
- Practical experience within a research environment and/or publication in relevant and refereed journals
- Knowledge of gene expression analysis
- Knowledge of research methods and statistical procedures
- Knowledge of research immunoblotting
- Knowledge of in vivo animal experimentation, preferentially nerve and spinal injuries
- Ability to conduct a detailed review of recent literature
- Creative approach to problem-solving
- Excellent verbal communication skills and the ability to deal with a wide range of people
- Excellent written communication skills and the ability to write clearly and succinctly for publication
- Ability to organise own work with mínimal supervision

**Further information**:
This is a full time and fixed term post for 3 years in the first instance. You will be based at the Hammersmith Campus (East Acton).
- The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes which are ultimately aimed towards finding new treatments and making scientific and medical advances, and where there are no satisfactory or reasonably practical alternatives to their use. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level._ _Find out more about animal research at Imperial_._

**Documents**:

- JD - July 2023.pdf


  • Research Associate

    2 months ago


    Hammersmith, United Kingdom Imperial College London Full time

    We are seeking a highly motivated Research Associate, to join a British Heart Foundation funded programme of research that aims to investigate the mechanosensitive regulation of myocardial contractility and electrophysiology by microvascular endothelial cells using human induced pluripotent stem cell-derived cardiomyocytes. **Duties and...

  • Research Associate

    2 months ago


    Hammersmith, United Kingdom Imperial College London Full time

    **Developing AI-ECG models for cardiovascular risk and mortality prediction** Through various collaborators worldwide, we have access to large quantities of digital ECGs (>2 million) recorded in clinical settings, in addition to >40000 digital ECGs from the UK Biobank linked to genetic and phenotypic data, which will allow us to train a range of AI-ECG...

  • Research Associate

    1 month ago


    Hammersmith, United Kingdom Imperial College London Full time

    Applications are invited for a Research Associate who will work under the direction of Professor Sadaf Ghaem-Maghami. The post is funded by Target Ovarian Cancer and it is aimed at recognising factors that determine whether ovarian tumour is immunogenic, depending on its genetic make-up. **Duties and responsibilities**: The post holder will carry out...

  • Research Associate

    2 months ago


    Hammersmith, United Kingdom Imperial College London Full time

    We are looking for a talented computational biologist / bioinformatician to join the Multiple Myeloma Research Group led by Professor Tassos KaradimitrisYou should be a highly motivated and creative Research Associate, or Assistant nearing PhD completion. The group’s research focus is on delineating transcriptional and epigenetic mechanisms of oncogenesis...

  • Research Associate

    1 month ago


    Hammersmith, United Kingdom Imperial College London Full time

    You will join a collaborative team, working with Dr David Owen (a clinical molecular pharmacologist) and Dr Samuel Barnes (Senior Lecturer, focussing on homeostatic neural-circuit plasticity). The preclinical project involves using longitudinal 2-Photon in vivo imaging techniques to measure calcium mediated neuronal activity and cortical blood flow in...

  • Research Associate

    2 weeks ago


    Hammersmith, United Kingdom Imperial College London Full time

    You will join a collaborative team, working with Dr David Owen (a clinical molecular pharmacologist) and Dr Samuel Barnes (Senior Lecturer, focussing on homeostatic neural-circuit plasticity). The preclinical project involves using longitudinal 2-Photon in vivo imaging techniques to measure calcium mediated neuronal activity and cortical blood flow in...

  • Research Associate

    1 week ago


    Hammersmith, United Kingdom Imperial College London Full time

    The Section of Nutrition is a laboratory at the forefront of nutritional research in particular the study of the impact of food on metabolism and the relationship with health and disease. The lab is currently involved in research into obesity and appetite circuits and in developing a new understanding between diet, gastrointestinal metabolism, whole body...

  • Research Associate

    2 months ago


    Hammersmith, United Kingdom Imperial College London Full time

    A Research Associate position is available** **within the Petter Brodin laboratory, Department of Immunology, and Inflammation, at Imperial College London. The post is funded by the Academy of Medical Sciences (AMS) and deals with experimental and computational analyses of individual immune cells in healthy children from birth to adolescence and from...

  • Research Associate

    2 months ago


    Hammersmith, United Kingdom Imperial College London Full time

    **Duties and responsibilities**: - To take initiatives in the planning of research - To work in close collaboration with in-house and extramural researchers - To identify and develop suitable techniques for data analysis, integration and visualisation - To ensure the validity and reliability of data - To maintain accurate and complete records of all...

  • Research Associate

    3 days ago


    Hammersmith, United Kingdom Imperial College London Full time

    The post is funded by the EPSRC to combine the High-Speed Scanning Ion Conductance Microscope (HS-SICM) developed in the lab and epi-illumination Selective Plane Illumination light sheet microscope (eSPIM) that is developed in the laboratory of Professor David Klenerman, University of Cambridge. The Research Associate will be expected to combine and maintain...

  • Research Associate

    2 weeks ago


    Hammersmith, United Kingdom Imperial College London Full time

    The project uses preclinical models to screen the potential of non-invasive brain stimulation regimes known to induce neuronal plasticity in the fight against AD. It involves a combination of non-invasive brain stimulation in preclinical models capturing features of AD-related pathology, _in vivo_ 1- and 2-Photon structure/function micro-circuit imaging,...

  • Research Associate

    1 month ago


    Hammersmith, United Kingdom Imperial College London Full time

    We have an exciting opportunity to appoint a talented and ambitious post-doctoral research assistant to join our multidisciplinary 3-year collaborative project, funded by the Medical Research Council entitled: “_An integrative transethnic approach to identify novel functional genes in Parkinson's disease using in silico and in vivo...

  • Research Associate

    1 week ago


    Hammersmith, United Kingdom Imperial College London Full time

    Research in the Division of Neuroscience addresses mechanisms that underpin nervous system functions and diseases. Investigators in the Division are exploring these through combinations of neurophysiological, anatomical, molecular, cellular and computational approaches, using pre-clinical models and clinical studies. Exciting research developments have...

  • Research Associate

    4 days ago


    Hammersmith, United Kingdom Imperial College London Full time

    Neuroactive natural products have led to important drugs including anthelmintics and pharmaceuticals, but we have barely scratched the surface of what nature has to offer. How will we discover the next generation of neuroactive compounds? We have developed new technology for high-throughput behavioural screening and quantitative phenotyping that will enable...

  • Research Associate

    3 weeks ago


    Hammersmith, United Kingdom Imperial College London Full time

    AAV is a life-threatening multisystem disease characterized by necrotizing inflammation of small blood vessels and deleterious organ damage. Early disease control by targeted treatment has improved outcomes considerably, but the most important clinical challenge now is the recognition and control of flares. This project aims to delineate the immunological...

  • Research Associate

    5 days ago


    Hammersmith, United Kingdom Imperial College London Full time

    We are looking for two highly motivated and driven researchers with a PhD or equivalent and a strong background in molecular and/or cellular biology to join the research group led by Dr Aida Martinez-Sanchez within the section of Cell Biology and Functional Genomics at Imperial College London (ICL). Our lab is based at the Imperial Centre for Translational...

  • Research Associate

    3 days ago


    Hammersmith, United Kingdom Imperial College London Full time

    We focus on the role of key neural-circuit plasticity processes thought to be critical for healthy network function. To achieve this, we use preclinical mouse models and cutting-edge technologies including 1- and 2-Photon in vivo microscopy, electrophysiology, automated behavioural testing, single cell/nuclei transcriptomics, non-invasive brain stimulation,...


  • Hammersmith, United Kingdom Imperial College London Full time

    Veselkov's Lab is in search of a skilled and motivated Research Associate to work on projects centred around developing deep learning, reinforcement learning, and graph neural networks. The goal of these projects is to analyse multi-source imaging and omics data in the fields of cancer research and computational medicine. We are seeking a passionate...

  • Research Assistant

    7 days ago


    Hammersmith, United Kingdom Imperial College London Full time

    Dementia is the greatest health challenge of our century._ To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it. The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this...


  • Hammersmith, United Kingdom Imperial College London Full time

    Applications are invited for a Research Associate position within a project that strives to develop new methodologies to address the current gaps in our knowledge and lead to establishing a tool that will assess diet-induced non-communicable disease (NCD) risk. The project is funded by EU HORIZON and UKRI and titled "CoDiet: Combating diet related...