Research Associate
2 months ago
Research in the Division of Neuroscience addresses mechanisms that underpin nervous system functions and diseases. Investigators in the Division are exploring these through combinations of neurophysiological, anatomical, molecular, cellular and computational approaches, using pre-clinical models and clinical studies.
The post is funded by funds to Di Giovanni’s lab to investigate the molecular and cellular underpinnings of regenerative failure after nerve and spinal cord injuries.
To carry out research programmes in molecular and cellular underpinnings of regenerative failure after nerve and spinal cord injuries. The Research Associate will be expected to generate data of high quality that can be submitted for publication to high-profile refereed journals and to attract external research funding.
Exciting recent research developments have placed the role of axonal signalling and transcriptional regulation at the centre of the capacity of axons to re-grow after spinal cord injury. These include work from our laboratory (see Di Giovanni S, on PubMed). Given that neurological recovery and axonal regeneration are not possible following a spinal injury, understanding how the re-growth of injured axons is controlled is key to enhancing axonal regeneration and potentially functional recovery. Axonal signalling and metabolic control seem important for modulating the complex gene expression program necessary for the regrowth of an axon. However, the role of environmental factors in signalling and metabolic pathways in axonal regeneration remains obscure.
**Duties and responsibilities**:
- To take initiatives in the planning of research
- To direct the work of small research teams
- To identify and develop suitable techniques, and apparatus, for the collection and analysis of data
- To conduct data analysis
- To ensure the validity and reliability of data at all times
- To maintain accurate and complete records of all findings
- To write reports for submission to research sponsors
- To present findings to colleagues and at conferences
- To submit publications to refereed journals
**Essential requirements**:
- **Research Associate**: Hold or be about to obtain a PhD in Neuroscience a closely related discipline, or equivalent research, industrial or commercial experience
- ** Research Assistant**: Near completion of a PhD in Neuroscience a closely related discipline, or equivalent research, industrial or commercial experience- Practical experience within a research environment and/or publication in relevant and refereed journals
- Practical experience in a broad range of techniques including in molecular and cellular biology, as well as in in vivo murine work
- Practical experience within a research environment and/or publication in relevant and refereed journals
- Knowledge of gene expression analysis
- Knowledge of research methods and statistical procedures
- Knowledge of research immunoblotting
- Knowledge of in vivo animal experimentation, preferentially nerve and spinal injuries
- Ability to conduct a detailed review of recent literature
- Creative approach to problem-solving
- Excellent verbal communication skills and the ability to deal with a wide range of people
- Excellent written communication skills and the ability to write clearly and succinctly for publication
- Ability to organise own work with mínimal supervision
**Further information**:
This is a full time and fixed term post for 3 years in the first instance. You will be based at the Hammersmith Campus (East Acton).
- The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes which are ultimately aimed towards finding new treatments and making scientific and medical advances, and where there are no satisfactory or reasonably practical alternatives to their use. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level._ _Find out more about animal research at Imperial_._
**Documents**:
- JD - July 2023.pdf
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