Research Associate

We focus on the role of key neural-circuit plasticity processes thought to be critical for healthy network function. To achieve this, we use preclinical mouse models and cutting-edge technologies including 1- and 2-Photon in vivo microscopy, electrophysiology, automated behavioural testing, single cell/nuclei transcriptomics, non-invasive brain stimulation, Imaging Mass Cytometry and computational modelling.

As a Research Associate in the lab, you will join a collaborative and highly skilled team. You will take a leading role on a project to further the knowledge of Alzheimer’s disease by determining key molecular mechanisms of dysregulated homeostasis by ageing and/or early-stage amyloid pathology. This information will be used to develop novel (or repurpose existing) intervention strategies to boost homeostatic control and stabilise pathophysiological neuronal firing-rate activity.

This role is part of the UK Dementia Research Institute at Imperial, located in the Department of Brain Sciences. Postdocs here enjoy excellent career development opportunities with:

- Access to a range of cutting-edge technologies, i.e., 1- and 2-Photon _in vivo_ microscopy, electrophysiology, automated behavioural testing, single cell/nuclei transcriptomics, non-invasive brain stimulation, IMC and computational modelling.
- An inclusive, collegial, team-oriented working environment.
- Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.
- Support from the Postdoc and Fellows Development Centre (PFDC) and ECR Communities
- The opportunity to mentor, supervise and teach students.

**Duties and responsibilities**:
You will:

- Build on existing skills and experience to address major components of this project independently.
- Present research findings as written reports, at conferences, within the College and as published manuscripts.
- Take initiative in research planning, with clear and timely communications to the Group Leader and relevant researchers.
- Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students
- Provide guidance to staff and assist in the supervision of research students, as required
- Maintain highly organised and accurate records of experimental work
- Undertake appropriate scientific and professional training.

**Essential requirements**:
You will be a **motivated and organised researcher**, excited by the science we do.

You will hold (or be near completion of) **a PhD in neuroscience** (or related discipline), with practical experience of 2-Photon _in vivo_ imaging of mouse models and/or associated synaptic plasticity and neuronal micro-circuit experience.

Experience of one or more **software** packages is essential: MATLAB, ImageJ, SigmaPlot, Prism, R as is experience in statistical analysis.

**Further information**:
**This position is offered full time, fixed term initially for a period of one year with the potential for renewal, this role will be based at Hammersmith Campus.**

Appointments are typically made to the first spine point of the scale. Applicants who have not yet had their PhD degree awarded will be appointed to the Research Assistant scale.
- Closing date: _**_2 WEEKS AFTER LISTING OR THE FOLLOWING MONDAY IF CLOSING FRI - SUN_**

**Documents**:

- JD_Research Associate Final Sr.pdf