Post-doctoral Research Associate

4 months ago

Leicester, United Kingdom University of Leicester Recruitment Team Full time

**About the role**:

- _
This post is supported by the van Geest Foundation Heart and Cardiovascular Diseases Research Fund, looking at ‘Validation of a Human Aortic Valve Stenosis Model for Studying Novel Therapeutic Targets’. You will join a dynamic and successful research group.

You will be based at the University of Leicester Clinical Sciences building at Glenfield Hospital. Research infrastructure includes a NIHR Biomedical Research Centre (BRC), and a BHF-funded Clinical Research Centre. You will work closely with Dr Katy Roach, Prof. Peter Bradding, Dr Anvesha Singh, Prof. Don Jones and Dr Rick Joshi, who are all collaborators on the project grant.

Aortic stenosis (AS), or narrowing of the aortic valve, is the commonest heart valve disease requiring surgery. It is caused by ‘wear and tear’ of the valves and is associated with ageing, and so is on the rise as people are living longer. There are no medications that can slow down or reverse the narrowing, and the only treatment is to replace the valve, usually through open-heart surgery. There is therefore an unmet need to develop medical treatments for this common condition.

The aim of this project is to validate the use of cultured AS valves to investigate novel therapies. Using cultured AS valve leaflets, we will examine whether potential anti-fibrotic compounds downregulate the pro-fibrotic and pro-calcific molecular pathways that are active within AS valves. To do this, we will perform RNA sequencing and mass spectrometry to elucidate changes in the transcriptome and proteome respectively. In addition, we will use spatial transcriptomics (GeoMx, nanoString), allowing spatial analysis of the transcriptomic and protein changes, and localisation to specific cell types such as myofibroblasts and endothelial cells.

**About you**:_ _
We require a 50% FTE post-doc for 1 year to run the experiments, prepare samples for downstream experiments and perform analysis. Knowledge of transcriptomic and proteomic sample preparation and mass spectrometric acquisition of data for complex downstream bioinformatic pathway analysis is mandatory.

**Additional information**:
Applications for job share will be considered.

As part of the University’s ongoing commitment to professional development, this role will also be considered on a seconded basis for existing staff members. Please ensure this is discussed with your line manager prior to applying. More information regarding secondments can be found here

The University of Leicester has been changing the world, and changing people’s lives, for 100 years. When you join us, you’ll become part of a community of Citizens of Change, which includes not only our staff and our current students but also thousands of Leicester graduates around the world.

As a diverse and forward-thinking employer, we embed the principles of equity, diversity and inclusion into everything we do. That includes not just our core missions of teaching and research, but also our support for staff, students and our local community through our values of Inspiring, Impactful and Inclusive through our values of Inspiring, Impactful and Inclusive.

We’re committed to the wellbeing of all our staff and to the sustainability of our environment, on our campus and beyond. We offer a competitive salary package, excellent pension scheme and a generous annual leave allowance, along with opportunities to develop your career in a supportive and collaborative environment.

**Vacancy terms**: Part-time (0.5FTE, 18.75 hours per week), or job share considered, fixed term contract 0.5 FTE for 1 year

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