Senior Research Associate

2 weeks ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Salary**: £44,414 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 01 August 2023

The Role

We are seeking a motivated Senior Research fellow to join our group of investigators (Lako, Armstrong, Korolchuk and Steel) at Bioscience Institute to investigate choroid endothelial cell loss in Age Related Macular Degeneration (AMD) using a patient specific iPSC model. The Senior Research fellow will generate the control and patient specific choroid endothelial cells and assess the role of complement activation on their survival and transcriptome. Further the senior research fellow will perform pharmacological screens to rescue choroid endothelial cell loss in AMD patients. This project is funded by Macular Society UK and follows from our recent work on generation and characterisation of AMD specific RPE cells (PMID: 36544284, PMID: 32815311, PMID: 28913923) and single cell RNA-Seq of AMD choroid and RPE cells (PMID: 36645183).

A scientific background on pluripotent stem cell culture and differentiation to retinal organoids, RPE cells or choroid endothelial cells, immunofluorescence analyses of mouse retinas and retinal biology will be essential and applicants with record of accomplishment and expertise in complement biology and pharmacological drug screening would be advantageous.

The post-holder will work under the direction of investigators from September 2023 fulltime for 2.5 years on a fixed term contract.

As part of our commitment to career development for research staff, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Key Accountabilities
Perform the differentiation of human pluripotent stem cells to choroid endothelial cells
Fully characterise choroid endothelial cells using a combination of immunofluorescence, Elisa and western blot-based assays
Assess the role of complement activation in choroid endothelial cell loss in AMD patients
Perform pharmacological screens to rescue choroid endothelial cell loss in AMD patients
Lead the team of researchers involved in this project with respect to experimental planning and co-ordination of various assays performed in collaborating laboratories
Regular liaison with the Investigators and researchers working on retinal and stem cell differentiation team and collaborators to ensure high quality of research and timely delivery of the project goals
Perform data extraction and analysis and ensure full compliance with existing ethical regulations as appropriate
Lead on the production of high-level scientific information including analysing, writing and presenting reports and manuscripts relevant to the transplantation work
Continuously review the literature and technology relevant to the project and ensure that the outputs of the project are positioned appropriately in relation to other on-going work.
Supervise PhD, MRes and BSc project students

The Person (Essential)

Knowledge, Skills and Experience
Knowledge of retinal development
Experience in generation of retinal organoids, RPE or choroid endothelial cells from pluripotent stem cells
Experience in tissue processing and immunohistochemistry or RNA-Scope
Experience of molecular assays (RNA-Seq, Elisa, western blots)
Experience of setting up pharmacological screens and respective data analyses
Desirable
Supervision of PhD students
Experience of lab management
Evidence of an excellent record of research including publication and presentation of data at conferences

Attributes and Behaviour
High level laboratory skills
Excellent organisation
Attention to detail
Quick to learn new skills
IT literate and competent
Able to communicate effectively at all levels
Able to analyse and interpret data
Strong critical thinking skills
Evidence of good oral communication skills; flexible independent working; initiative; and ability to work as part of a multi-disciplinary team
Excellent interpersonal skills
Able to prioritise key task and meet deadlines
Willingness to work outside normal hours and weekends as necessary
Highly Motivated and enthusiastic
Desirable
Experience of supervision of junior staff members
Experience of managing/organising lab

**Qualifications**:
Newcastle University is a global University where everyone is treated with dignity and respect. As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.

At Newcastle University we hold a silver Athena Swan award in recognition of our good employment practices for the advancement of gender equality. We also hold a Race Equality Charter Bro

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