Research Associate

2 weeks ago


South Kensington, United Kingdom Imperial College London Full time

We are seeking to appoint a Research Associate to join a world-leading and dynamic research team at the Department of Life Sciences at Imperial College London. You will contribute to a research effort by the laboratory of Dr Angela Meccariello based at Imperial’s South Kensington Campus. The project aims to build and improve CRISPR design engineering, based on the use of CRISPR/Cas9, as well as other technologies with the ultimate goal of pest control by implementing pgSIT in the Mexfly populations.

The goal of the project is to develop new and innovative genetic control offers a species-specific approach to tackle this problem by delivering novel traits into target populations via the release of modified insects to therefore reduce the population size of harmful pest organisms. Mainly it will rely on the use of CRISPR/Cas9 technology to establish a precison-guided Sterile Insect Technique in the Mexfly. The project is part of a wider collaborative network; thus the role will involve a high degree of teamwork and interdisciplinary research.

You must be in possession of a PhD focused on Tephritid pest control. Demonstrable experience of working with Tephritids, as well as a good knowledge of Tephritid genetics and transgenesis, and practical experience of working within a highly competitive research environment in the relevant field. An emerging successful track record of academic publications commensurate with experience is also essential. Good knowledge of genomics and experience in Tephritids biology is desirable.

**Duties and responsibilities**:

- To take initiatives in the planning of research and conduct data analysis.
- To rear a Mexfly colony, carry out embryo microinjections and set up genetic experimental crosses
- To carry out tissue dissections and genomic DNA and RNA extraction from Mexfly samples
- To keep the conditions and hygiene of insectary facilities at a high standard
- To prepare and carry out experiments following guidelines and analyse results using a range of agreed procedures
- To contribute to the preparation of grant reports to funder, scientific publications and regular technical updates.
- To collaborate with other allied scientists within Imperial College and elsewhere in London and abroad as appropriate.
- To regularly discuss progress of research projects with members of the Group.
- To acquire and interpret research data and results.
- To maintain accurate and complete records of all findings.

**Other responsibilities**
- To organize and supervise dedicated class activities or practical work for lab members and undergraduate students when required.
- To present findings to colleagues and at conferences.
- To promote the reputation of the Group, the Department and the College.
- To undertake any necessary training and/or development.

**Essential requirements**:

- Hold, or be near completion of, a PhD in an appropriate biological science with a strong focus on Tephritid pest control.
- Previous experience with Tephritid genetics and Mexfly rearing.
- High level of expertise and skills in molecular/synthetic biology.
- Track record of publications in peer-reviewed journals.
- Previous experience of Mexfly embryo mucroinjections.

**Further information**:
***_The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level._

**Documents**:

- Job Description Research Associate.pdf


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