Research Scientist

2 months ago

Stevenage Hertfordshire, United Kingdom Spur Therapeutics Full time

Gene therapy is at an inflection point. Amidst the noise of countless emerging modalities, we've been hard at work refining our science and advancing our programs with quiet determination and a bold ambition to unlock the true potential of gene therapy to change the trajectory of more patients' lives. Come join Spur's dedicated team of scientists, physicians and other professionals who are singularly focused on using cutting-edge science and technology to transform the treatment of serious and debilitating chronic diseases.

We are a clinical-stage biotech company developing transformative adeno-associated virus (AAV) vector-mediated gene therapies. Founded in 2015, Spur is focused on developing innovative, one-time treatments that set new standards of care. Our integrated gene therapy platform includes in-house capabilities in research, protein engineering and clinical development, and we optimize every component of our product candidates to develop first- and best-in-class gene therapies. We are currently advancing a highly differentiated gene therapy candidate in a Phase 1/2 clinical trial in people with Gaucher disease. We are working on additional programs in research, with a focus on CNS and cardiovascular diseases, to reach even more patients with our potentially life-changing treatments. Spur is global, with research facilities and offices in Stevenage, UK, and offices in Boston and New York.

We are relentless in our pursuit of transformative medicines for patients. We take innovation seriously and know we need to be bold both in our science and in every aspect of our work. This is a hybrid role, located in Stevenage, UK.

A Senior Scientist will work independently and as part of a team in this lab-based role.
They will be instrumental in the set up and handling of bioreactors and manufacturing research/nonclinical grade viral vectors (particularly AAV) & recombinant proteins using mammalian cell suspension systems.
They will play a leading role in the execution, analysis, quality control and presentation of data within their line of work.
Design, execute and write up scientific experiments in a timely manner and with high quality.
Provide project summaries and reports, as required, and adhere strictly to established quality standards and accurate record keeping, essential for on-going activities
They will ensure knowledge/technique transfer to and training of junior staff and colleagues.
The Senior scientist will be supported by their line manager with frequently and regular meetings to discuss progress towards goals (company- and career-based) and development activities.
Take a role in partnering with our internal CMC team for transfer of the manufacturing & quality aspects of the product from Research to CMC.
Support work involving external collaborations and Contract Development & Manufacturing Organizations (CDMOs).
They will source/develop and evaluate technologies and processes for AAV batches with improved yield, quality & beneficial impurity profile.

Scientific training and background in the following areas:
~ Experience in conducting Design of Experiment (DoE) studies & understanding of biochemical analytical monitoring of bioreactors.
~ Evidence of scientific accomplishments in the form of publications and presentations.
~ Strong critical, scientific, and strategic thinking skills; Experience interpreting and presenting data to internal and external stakeholders, and meetings
~

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