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Part-time Researcher

4 months ago

Worcester Worcestershire, United Kingdom MediRecruit Full time

View Vacancy -- Senior Researcher – Chemistry - NATA 2405
Research Institute NATA
Research Institute / Unit Information Nucleic Acid Therapy Accelerator
The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), have invested a total of £30m over 4 years through the Strategic Priorities Fund to establish a nucleic acid therapy accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid drug delivery, through focused NATA research challenges and a NATA infrastructure hub. This will be an internationally unique resource, drawing on world-leading academic expertise in partnership with innovative businesses to discover and test viable ways of delivering oligonucleotide therapies, anchoring the oligonucleotide therapy industry in the UK for many years to come.
The NATA will focus on bringing together key stakeholders around the infrastructure hub while catalysing collaborative R&D activity with focused support to tackle significant barriers facing oligonucleotide therapy delivery to key organs. This investment will support capacity building in terms of equipment, upskilling and domain expertise that will be essential in developing critical mass to catalyse and de-risk the development of next generation nucleic acid medicines.
The NATA has the opportunity to establish a new industrial sector attracting and developing highly skill jobs with the potential of the UK being the leader in the field where global nucleic acid therapies market is expected to be £6 billion by 2025.
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at
Contract Type Permanent
Job Type Science
Full Time / Part Time Full Time
The senior scientist will be critical in supporting the NATA chemistry department by being a key member of the chemistry team supporting the design, synthesis and development of new and novel therapeutic oligonucleotides for various translational and collaborative projects. The successful candidate will both work independently and be part of project teams. This individual will be involved in the design, development and testing of novel chemical modalities for Nucleic Acid delivery. Serve as a key member in optimizing current Nucleic Acid Therapeutic platform, development of new chemical modalities and production of multiple lead compounds.
Play an active role in synthesis, purification and analysis of novel nucleosides, phosphoramidites and oligonucleotides with minimal supervision.
Contribute to advanced conjugation chemistry.
Write and submit manuscripts for publication with the Chemistry Lead R and I.
Managing chemistry laboratory resources efficiently and troubleshooting equipment and synthetic procedures.
Conducting quality control and preparing data sheets.
Keeping excellent scientific records and implementing databases.
Presenting work internally, externally and contributing to lab meetings.
Provide regular updates on project status to the Chemistry Lead R and I.
Participate in supervising R & D activities at external contract research organizations.
Support quality control duties when necessary.
Undertake any necessary training that contributes to the development of the main responsibilities.
PhD degree in Chemistry with expertise in synthetic organic chemistry, oligonucleotide chemistry or nucleoside/nucleic acid chemistry. Post-PhD postdoctoral or industrial experience preferred, however fresh PhDs with excellent track record will also be considered.
Extensive experience of working in a chemistry lab (academia or industry) conducting air/moisture sensitive reactions.
Proficient in characterization techniques such as LC-MS, HRMS, NMR etc (including data analysis and interpretation).
Expertise in conjugation chemistry.
Computer Literacy; should be familiar with chemistry softwares like Chemdraw and Mestrenova and search tools like Scifinder/Reaxys.
Experience in draft ing research articles and patents for publication.
Knowledge in bioinformatics.
Interdisciplinary interests with an emphasis on chemical biology.
Experience in large data set analysis and database management.
The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
Medical Research Council
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