PhD Studentship: Controlling Greenhouse Gas Emissions by Targeting Bacterial G-quadruplex DNA/RNA Structures
Found in: beBee jobs GB - 2 weeks ago
Primary supervisor - Dr Andrew Gates
As well as carbon dioxide (CO2), other important climate-active gases are known to drive global warming. Importantly, nitrous oxide (N2O), is the third most abundant greenhouse gas with 300-times greater global warming power than CO2 and it also contributes to the destruction of the ozone layer. Production of N2O is a by-product of modern farming, where after applying fertilizers, soil-based bacteria consume nitrate and generate N2O that is emitted from soil to the atmosphere. By understanding how bacteria do this and developing tools to control it, we could potentially reduce future biological N2O emissions, allowing recovery of the ozone layer and help reduce global climate change while continuing to feed expanding global populations.
This PhD project will develop understanding of how DNA and RNA structures control nitrogen assimilation and N2O production in bacteria and how we can use small-molecules to control these pathways in cells. The project will provide training in a wide-range of state-of-the-art biophysical, molecular biology and microbiological techniques, from characterizing different types of DNA/RNA structures, gene expression studies to ligand-binding assays. Led by Dr Andrew Gates, this project will be based in the School of Biological Sciences at the University of East Anglia (UEA) and the student will work collaboratively with Dr Yiliang Ding at the John Innes Centre and Dr Zoë Waller (UEA/UCL).
The student will have, or expect to obtain a first class, 2(i) or equivalent honours degree in Microbiology, Biochemistry, Chemistry, Pharmacy or a related area. Informal enquiries are welcomed; for further information please contact Dr Andrew Gates.
This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will potentially be interviewed on 4, 5, and 6 June 2024.
For further information on eligibility and how to apply please visit here.
Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Master's degree. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2023/4 stipend rate: £18,622), and a Research Training Support Grant of £5,000pa for each year of the studentship.
Competition Funded (Home) - see advert for details
-
PhD Studentship: Unravelling the Role of Genotoxic E. Coli in Colorectal Cancer
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Stephanie SchüllerColorectal cancer (CRC) is the third most common and second most fatal cancer globally. Most cases of CRC are not hereditary but influenced by lifestyle factors and changes in the gut microbiome. Importantly, 5-10% of CRCs have been linked to E. coli strains producing the metabolite colibactin which causes DNA...
-
PhD Studentship: New Tools for Old Foes: Developing a New Class of Antimicrobial Metallodrugs
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr Rianne Lord Bacterial infections are the second-leading cause of deaths globally, and whilst antibiotics have undoubtedly saved millions of lives, their extensive use, coupled with pathogen evolution has resulted in drastic increases in prevalence of antibiotic-resistant strains. Amongst these, Gram-negative pathogens pose the most...
-
PhD Studentship: ThAnoS: Thiopeptide Antibiotics Biosynthesis
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Dmitry Ghilarov BackgroundThe acute problem of antimicrobial resistance incentivises us to develop innovative approaches to antibiotic discovery & production. Natural products that form the basis of our current medical arsenal are often difficult to synthesize, purify, or engineer. In recent years bioinformatically predicted peptide...
-
PhD Studentship: Signalling Mechanism Enhancing Root Nodule Symbiosis
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost, giving rise to soil and water pollution as well as global...
-
PhD Studentship: Spatial Orientation Changes and Their Impact on Driving in Ageing and Dementia
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timeThe PhD project will be supervised by Prof. Michael Hornberger (dementia neuroscientist, University of East Anglia). Please contact the supervisor at for further information on the project. We have an exciting PhD studentship to work on how spatial navigation changes impact driving behaviour in older people and dementia. The project builds upon our prior...
-
PhD Studentship: Dietary Adaptation of Bifidobacterium in the Weaning Infant Gut
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult diet. The genus Bifidobacterium has several adaptations making it...
-
PhD Studentship: The Role of the Extracellular Matrix in Cardiomyocyte Developmental
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr James Smith Cardiomyocytes are the muscle cells of the heart, responsible for the production of contraction forces. During development, cardiomyocytes withdraw from the cell-cycle and switch from proliferative, growth to non-proliferative, hypertrophic growth. It is becoming clear that the extracellular matrix molecules play a key role...
-
PhD Studentship: Developing Improved Diagnostic Tests for Vitamin B12
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Martin Warren This PhD opportunity is ideal for graduates in biochemistry or biomedical science with a keen interest in protein science and its application in developing new diagnostic tests and assays. Recently, the National Institute for Health and Care Excellence (NICE) issued comprehensive guidelines on diagnosing and...
-
PhD Studentship: Epigenetic Profiling of Cereal Fungal Invaders
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be recognised...
-
PhD Studentship: Linking Metabolism and Metal Resistance in Pathogenic Bacteria
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timeGroup B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Little is known about how GBS resists the immune system and colonises to cause invasive disease. This PhD will develop a new understanding of how streptococci resist intoxication by metals, a major...
-
PhD Studentship: Exploring the Roles of a Novel Prion-like Protein in Stress Resistance and Ageing
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these functions would increase our understanding of the behaviour and...
-
PhD Studentship: Ticking Clocks, Thriving Crops: Developing Climate-Resilient Crops Through Circadian Biology
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Antony Dodd Climate change poses a significant threat to our food supply, but you can be part of the solution In this groundbreaking research project, we're investigating how plants adapt to changing seasons and temperatures, with a focus on ensuring robust crop production despite environmental challenges.You'll explore the...
-
Postdoctoral Research Scientist
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom Earlham Institute Full timeApplications are invited for a Postdoctoral Research Scientist to join the Laboratory of Dr Wilfried Haerty in the Research Faculty of the Earlham Institute, based in Norwich, UK.Background:Climate change imposes unprecedented challenges to organisms, both through the rapid change of their environment (e.g. temperature increase, droughts) and through...
-
Mechanical Engineer
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom Select Full timeSelect are currently recruiting for Mechanical Engineers for our client on the outskirts of Norwich. Is your expertise in Mechanical Engineering, with a focus on developing innovative mechanical solutions? My client is seeking a skilled individual to join their team, offering a unique opportunity to apply your skills in a challenging and rewarding...
-
Manufacturing Engineer
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom Service Service Employment Agency Limited Full timeAn electrical/electronics engineering organisation near Norwich airport is seeking a Manufacturing Engineer to support continuous production within a clean, bright and open manufacturing facility. A typical day in the life of a Manufacturing Engineer (ME) always starts with a Daily Management Team meeting to discuss what happened yesterday and what's planned...
-
Manufacturing Engineer
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom Fortive Full timeDay in the Life of a Manufacturing EngineerA typical day in the life of a Fluke Norwich Manufacturing Engineer (ME) always starts with a Daily Management Team meeting to discuss what happened yesterday and what's planned for today. Who needs help in what area and what the team needs to do today to be successful.Success revolves around supporting Production...
-
PhD Studentship: Controlling Greenhouse Gas Emissions by Targeting Bacterial G-quadruplex DNA/RNA Structures
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Andrew Gates As well as carbon dioxide (CO2), other important climate-active gases are known to drive global warming. Importantly, nitrous oxide (N2O), is the third most abundant greenhouse gas with 300-times greater global warming power than CO2 and it also contributes to the destruction of the ozone layer. Production of N2O is a...
-
PhD Studentship: New Tools for Old Foes: Developing a New Class of Antimicrobial Metallodrugs
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr Rianne Lord Bacterial infections are the second-leading cause of deaths globally, and whilst antibiotics have undoubtedly saved millions of lives, their extensive use, coupled with pathogen evolution has resulted in drastic increases in prevalence of antibiotic-resistant strains. Amongst these, Gram-negative pathogens pose the...
-
PhD Studentship: Signalling Mechanism Enhancing Root Nodule Symbiosis
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost, giving rise to soil and water pollution as well as global...
-
PhD Studentship: ThAnoS: Thiopeptide Antibiotics Biosynthesis
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Dmitry Ghilarov Background The acute problem of antimicrobial resistance incentivises us to develop innovative approaches to antibiotic discovery & production. Natural products that form the basis of our current medical arsenal are often difficult to synthesize, purify, or engineer. In recent years bioinformatically predicted...
-
PhD Studentship: Spatial Orientation Changes and Their Impact on Driving in Ageing and Dementia
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timeThe PhD project will be supervised by Prof. Michael Hornberger (dementia neuroscientist, University of East Anglia). Please contact the supervisor at m.hornberger@uea.ac.uk for further information on the project. We have an exciting PhD studentship to work on how spatial navigation changes impact driving behaviour in older people and dementia. The...
-
PhD Studentship: Dietary Adaptation of Bifidobacterium in the Weaning Infant Gut
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult diet. The genus Bifidobacterium has several adaptations...
-
PhD Studentship: Linking Metabolism and Metal Resistance in Pathogenic Bacteria
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timeGroup B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Little is known about how GBS resists the immune system and colonises to cause invasive disease. This PhD will develop a new understanding of how streptococci resist intoxication by metals, a major...
-
PhD Studentship: Developing Improved Diagnostic Tests for Vitamin B12
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Martin Warren This PhD opportunity is ideal for graduates in biochemistry or biomedical science with a keen interest in protein science and its application in developing new diagnostic tests and assays. Recently, the National Institute for Health and Care Excellence (NICE) issued comprehensive guidelines on diagnosing and...
-
PhD Studentship: The Role of the Extracellular Matrix in Cardiomyocyte Developmental
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr James Smith Cardiomyocytes are the muscle cells of the heart, responsible for the production of contraction forces. During development, cardiomyocytes withdraw from the cell-cycle and switch from proliferative, growth to non-proliferative, hypertrophic growth. It is becoming clear that the extracellular matrix molecules play a key...
-
PhD Studentship: Epigenetic Profiling of Cereal Fungal Invaders
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be...
-
PhD Studentship: Ticking Clocks, Thriving Crops: Developing Climate-Resilient Crops Through Circadian Biology
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Antony Dodd Climate change poses a significant threat to our food supply, but you can be part of the solution! In this groundbreaking research project, we're investigating how plants adapt to changing seasons and temperatures, with a focus on ensuring robust crop production despite environmental challenges. You’ll explore...
-
PhD Studentship: Exploring the Roles of a Novel Prion-like Protein in Stress Resistance and Ageing
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these functions would increase our understanding of the behaviour...
-
Postdoctoral Researcher
Found in: Talent UK C2 - 1 week ago
Norwich, United Kingdom John Innes Centre Full timeAn exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre, working in collaboration with the Hutchings lab, on a project titled: Manipulating two-component systems to activate cryptic antibiotic pathways in filamentous actinomycete bacteria. About the Wilkinson Group We are an...
-
Laboratory Technician – Food Structure
Found in: Talent UK C2 - 1 week ago
Norwich, United Kingdom NBI Partnership Full timeJob Description Main Purpose of the Job The Laboratory Technician should provide a high standard of technical support to academic and research staff in the Quadram Institute. The post holder will maintain working areas following protocols, good laboratory practice and to support the ‘Food Structure and Bioaccessibility Facility’. They...
-
Integrity Engineer Structures
2 weeks ago
Norwich, United Kingdom CareerBliss Full timeIntegrity Engineer StructuresOur client, a leading independent Oil & Gas operator, based in Norwich, is currently seeking an Integrity Engineer Structures, to join our clients team.This is a full-time position, which can be completed on either a permanent or contract basis.This is based in Norwich with the requirement to travel offshore periodically. You...
-
Postdoctoral Researcher
Found in: Talent UK C2 - 4 days ago
Norwich, United Kingdom John Innes Centre Full timeApplications are invited for a Postdoctoral researcher to join the group of Prof Saskia Hogenhout (twitter: @SaskiaHogenhout) at the John Innes Centre (JIC) to study phytoplasma effectors in human and animal cells and animal model systems. Our established system involves that are insect-vectored plant pathogens. Phytoplasmas have the remarkable ability to...
-
Integrity Engineer Structures
1 week ago
Norwich, United Kingdom Todd Hayes Ltd Full timeIntegrity Engineer StructuresOur client, a leading independent Oil & Gas operator, based in Norwich, is currently seeking an Integrity Engineer Structures, to join our clients team.This is a full-time position, which can be completed on either a permanent or contract basis click apply for full job details
-
Integrity Engineer Structures
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom Todd Hayes Ltd Remote Work Freelance Full timeIntegrity Engineer StructuresOur client, a leading independent Oil & Gas operator, based in Norwich, is currently seeking an Integrity Engineer Structures, to join our clients team.This is a full-time position, which can be completed on either a permanent or contract basis click apply for full job details
-
Senior Integrity Engineer Structures
1 week ago
Norwich, United Kingdom CareerBliss Full timeSenior Integrity Engineer StructuresOur client, a leading independent Oil & Gas operator, based in Norwich, is currently seeking a Senior Integrity Engineer Structures to join our clients Integrity team.This is a full-time permanent position, based in Norwich with the requirement to travel offshore periodically.You will report directly to the Structural...
-
Senior Integrity Engineer Structures
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom Todd Hayes Ltd Full timeSenior Integrity Engineer StructuresOur client, a leading independent Oil & Gas operator, based in Norwich, is currently seeking a Senior Integrity Engineer Structures to join our clients Integrity team.This is a full-time permanent position, based in Norwich with the requirement to travel offshore periodically click apply for full job details