PhD Studentship: Linking Metabolism and Metal Resistance in Pathogenic Bacteria
Found in: beBee S GB - 2 weeks ago
Group B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Little is known about how GBS resists the immune system and colonises to cause invasive disease.
This PhD will develop a new understanding of how streptococci resist intoxication by metals, a major antimicrobial effector of the human innate immune system. It will investigate how GBS uses metabolic pathways to counteract toxicity of zinc (Zn) or copper (Cu) when in these metals are found in excess. You will join energetic and well-resourced labs working at the forefront of this field in the medical microbiology discipline.
Expert multidisciplinary training will be provided in a wide array of advanced bacteriological, molecular, analytical and biochemical techniques to examine metal resistance mechanisms and characterise metabolic pathways in bacteria, e.g. genetic manipulation and generation of knockout mutations. You will make extensive use of cutting-edge sequencing technologies to study gene structure and function in GBS and use relevant models of disease. The specific focus can be tailored to your interests and you will be involved in all aspects of the study design, with access to outstanding research facilities across the Norwich Research Park and beyond. You will discuss your findings at weekly team and supervisory meetings where your training needs will be developed. You will have opportunities to present work at (inter)national conferences providing opportunities for networking with other scientists.
Your studies will be supervised by Dr Matthew Sullivan in the School of Biological Sciences and supported by funding from the Academy of Medical Science and the Faculty of Science, including for national conference atttendance to present your work to international experts. We are seeking a highly motivated applicant with strong interests in microbiology, biomedical science and molecular biology. Informal enquiries are welcome (matthew.sullivan@uea.ac.uk)
The standard minimum entry requirement is 2:1 (Hons) in Microbiology, Biomedical Science, Biomedicine, Biological Sciences, Molecular Biology, Biochemistry.
Additional Funding Information
This 3 year PhD studentship is funded by the Academy of Medical Science and the Faculty of Science. Applications are welcomed from UK applicants eligible for tuition fees at the ‘home’ rate only. Funding comprises ‘home’ tuition fees and an annual stipend of £18,622 (for a maximum of 36 months).
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PhD Studentship: Linking Metabolism and Metal Resistance in Pathogenic Bacteria
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timeGroup B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Little is known about how GBS resists the immune system and colonises to cause invasive disease. This PhD will develop a new understanding of how streptococci resist intoxication by metals, a major...
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PhD Studentship: Epigenetic Profiling of Cereal Fungal Invaders
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be recognised...
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PhD Studentship: New Tools for Old Foes: Developing a New Class of Antimicrobial Metallodrugs
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr Rianne Lord Bacterial infections are the second-leading cause of deaths globally, and whilst antibiotics have undoubtedly saved millions of lives, their extensive use, coupled with pathogen evolution has resulted in drastic increases in prevalence of antibiotic-resistant strains. Amongst these, Gram-negative pathogens pose the most...
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PhD Studentship: New Tools for Old Foes: Developing a New Class of Antimicrobial Metallodrugs
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr Rianne Lord Bacterial infections are the second-leading cause of deaths globally, and whilst antibiotics have undoubtedly saved millions of lives, their extensive use, coupled with pathogen evolution has resulted in drastic increases in prevalence of antibiotic-resistant strains. Amongst these, Gram-negative pathogens pose the...
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PhD Studentship: Epigenetic Profiling of Cereal Fungal Invaders
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be...
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PhD Studentship: Exploring the Roles of a Novel Prion-like Protein in Stress Resistance and Ageing
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these functions would increase our understanding of the behaviour and...
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PhD Studentship: Exploring the Roles of a Novel Prion-like Protein in Stress Resistance and Ageing
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these functions would increase our understanding of the behaviour...
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PhD Studentship: ThAnoS: Thiopeptide Antibiotics Biosynthesis
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Dmitry Ghilarov BackgroundThe acute problem of antimicrobial resistance incentivises us to develop innovative approaches to antibiotic discovery & production. Natural products that form the basis of our current medical arsenal are often difficult to synthesize, purify, or engineer. In recent years bioinformatically predicted peptide...
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PhD Studentship: ThAnoS: Thiopeptide Antibiotics Biosynthesis
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Dmitry Ghilarov Background The acute problem of antimicrobial resistance incentivises us to develop innovative approaches to antibiotic discovery & production. Natural products that form the basis of our current medical arsenal are often difficult to synthesize, purify, or engineer. In recent years bioinformatically predicted...
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PhD Studentship: Controlling Greenhouse Gas Emissions by Targeting Bacterial G-quadruplex DNA/RNA Structures
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Andrew Gates As well as carbon dioxide (CO2), other important climate-active gases are known to drive global warming. Importantly, nitrous oxide (N2O), is the third most abundant greenhouse gas with 300-times greater global warming power than CO2 and it also contributes to the destruction of the ozone layer. Production of N2O is a...
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PhD Studentship: Controlling Greenhouse Gas Emissions by Targeting Bacterial G-quadruplex DNA/RNA Structures
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Andrew Gates As well as carbon dioxide (CO2), other important climate-active gases are known to drive global warming. Importantly, nitrous oxide (N2O), is the third most abundant greenhouse gas with 300-times greater global warming power than CO2 and it also contributes to the destruction of the ozone layer. Production of N2O is a...
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PhD Studentship: Signalling Mechanism Enhancing Root Nodule Symbiosis
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost, giving rise to soil and water pollution as well as global...
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PhD Studentship: Signalling Mechanism Enhancing Root Nodule Symbiosis
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost, giving rise to soil and water pollution as well as global...
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PhD Studentship: Unravelling the Role of Genotoxic E. Coli in Colorectal Cancer
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Stephanie SchüllerColorectal cancer (CRC) is the third most common and second most fatal cancer globally. Most cases of CRC are not hereditary but influenced by lifestyle factors and changes in the gut microbiome. Importantly, 5-10% of CRCs have been linked to E. coli strains producing the metabolite colibactin which causes DNA...
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PhD Studentship: Spatial Orientation Changes and Their Impact on Driving in Ageing and Dementia
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timeThe PhD project will be supervised by Prof. Michael Hornberger (dementia neuroscientist, University of East Anglia). Please contact the supervisor at for further information on the project. We have an exciting PhD studentship to work on how spatial navigation changes impact driving behaviour in older people and dementia. The project builds upon our prior...
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PhD Studentship: Spatial Orientation Changes and Their Impact on Driving in Ageing and Dementia
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timeThe PhD project will be supervised by Prof. Michael Hornberger (dementia neuroscientist, University of East Anglia). Please contact the supervisor at m.hornberger@uea.ac.uk for further information on the project. We have an exciting PhD studentship to work on how spatial navigation changes impact driving behaviour in older people and dementia. The...
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PhD Studentship: Dietary Adaptation of Bifidobacterium in the Weaning Infant Gut
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult diet. The genus Bifidobacterium has several adaptations making it...
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PhD Studentship: Dietary Adaptation of Bifidobacterium in the Weaning Infant Gut
Found in: beBee S GB - 3 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult diet. The genus Bifidobacterium has several adaptations...
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PhD Studentship: The Role of the Extracellular Matrix in Cardiomyocyte Developmental
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr James Smith Cardiomyocytes are the muscle cells of the heart, responsible for the production of contraction forces. During development, cardiomyocytes withdraw from the cell-cycle and switch from proliferative, growth to non-proliferative, hypertrophic growth. It is becoming clear that the extracellular matrix molecules play a key role...
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PhD Studentship: Developing Improved Diagnostic Tests for Vitamin B12
Found in: beBee jobs GB - 3 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Martin Warren This PhD opportunity is ideal for graduates in biochemistry or biomedical science with a keen interest in protein science and its application in developing new diagnostic tests and assays. Recently, the National Institute for Health and Care Excellence (NICE) issued comprehensive guidelines on diagnosing and...