PhD Studentship: The Role of the Extracellular Matrix in Cardiomyocyte Developmental
Found in: beBee S GB - 2 weeks ago
Primary Supervisor: Dr James Smith
Cardiomyocytes are the muscle cells of the heart, responsible for the production of contraction forces. During development, cardiomyocytes withdraw from the cell-cycle and switch from proliferative, growth to non-proliferative, hypertrophic growth. It is becoming clear that the extracellular matrix molecules play a key role in regulating this switch, and specifically heparan sulfate proteoglycans (HSPGs). In this project, the student will investigate how HSPGs facilitate differential growth factor signalling to promote the switch from proliferation to maturation in cardiomyocytes.
This project will use state-of-the-art gene edited pluripotent stem cell models, to gain new insights relating to the mechanisms involved in regulating cardiomyocyte function. Training will be provided in the areas of stem cell biology, cardiac biology, differentiation, advanced flow cytometry, single cell sorting, RT-qPCR, and CRISPR/Cas9-based genome editing.
As well as the specific training detailed above, students will have access to high-quality training in scientific and generic skills, as well as access to a wide-range of seminars and training opportunities. The project will be carried out at the Smith Lab at the Bob Champion Research and Education building, Norwich Medical School, University of East Anglia.
This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will potentially be interviewed on 4, 5, and 6 June 2024.
For further information on eligibility and how to apply visit here.
Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.
Entry requirements
At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Master's degree. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category).
This project is awarded with a 4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD studentship. The studentship includes payment of tuition fees (directly to the University), a stipend to cover living expenses (2023/4 stipend rate: £18,622), and a Research Training Support Grant of £5,000pa for each year of the studentship.
Competition Funded (Home) - see advert for details
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PhD Studentship: The Role of the Extracellular Matrix in Cardiomyocyte Developmental
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr James Smith Cardiomyocytes are the muscle cells of the heart, responsible for the production of contraction forces. During development, cardiomyocytes withdraw from the cell-cycle and switch from proliferative, growth to non-proliferative, hypertrophic growth. It is becoming clear that the extracellular matrix molecules play a key role...
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PhD Studentship: Spatial Orientation Changes and Their Impact on Driving in Ageing and Dementia
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timeThe PhD project will be supervised by Prof. Michael Hornberger (dementia neuroscientist, University of East Anglia). Please contact the supervisor at for further information on the project. We have an exciting PhD studentship to work on how spatial navigation changes impact driving behaviour in older people and dementia. The project builds upon our prior...
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PhD Studentship: Spatial Orientation Changes and Their Impact on Driving in Ageing and Dementia
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timeThe PhD project will be supervised by Prof. Michael Hornberger (dementia neuroscientist, University of East Anglia). Please contact the supervisor at m.hornberger@uea.ac.uk for further information on the project. We have an exciting PhD studentship to work on how spatial navigation changes impact driving behaviour in older people and dementia. The...
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PhD Studentship: Dietary Adaptation of Bifidobacterium in the Weaning Infant Gut
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult diet. The genus Bifidobacterium has several adaptations making it...
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PhD Studentship: Signalling Mechanism Enhancing Root Nodule Symbiosis
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost, giving rise to soil and water pollution as well as global...
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PhD Studentship: Exploring the Roles of a Novel Prion-like Protein in Stress Resistance and Ageing
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these functions would increase our understanding of the behaviour and...
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PhD Studentship: Dietary Adaptation of Bifidobacterium in the Weaning Infant Gut
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult diet. The genus Bifidobacterium has several adaptations...
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PhD Studentship: Developing Improved Diagnostic Tests for Vitamin B12
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Martin Warren This PhD opportunity is ideal for graduates in biochemistry or biomedical science with a keen interest in protein science and its application in developing new diagnostic tests and assays. Recently, the National Institute for Health and Care Excellence (NICE) issued comprehensive guidelines on diagnosing and...
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PhD Studentship: ThAnoS: Thiopeptide Antibiotics Biosynthesis
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Dmitry Ghilarov BackgroundThe acute problem of antimicrobial resistance incentivises us to develop innovative approaches to antibiotic discovery & production. Natural products that form the basis of our current medical arsenal are often difficult to synthesize, purify, or engineer. In recent years bioinformatically predicted peptide...
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PhD Studentship: Signalling Mechanism Enhancing Root Nodule Symbiosis
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost, giving rise to soil and water pollution as well as global...
-
PhD Studentship: Exploring the Roles of a Novel Prion-like Protein in Stress Resistance and Ageing
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these functions would increase our understanding of the behaviour...
-
PhD Studentship: Epigenetic Profiling of Cereal Fungal Invaders
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be recognised...
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PhD Studentship: Developing Improved Diagnostic Tests for Vitamin B12
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Martin Warren This PhD opportunity is ideal for graduates in biochemistry or biomedical science with a keen interest in protein science and its application in developing new diagnostic tests and assays. Recently, the National Institute for Health and Care Excellence (NICE) issued comprehensive guidelines on diagnosing and...
-
PhD Studentship: ThAnoS: Thiopeptide Antibiotics Biosynthesis
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Dmitry Ghilarov Background The acute problem of antimicrobial resistance incentivises us to develop innovative approaches to antibiotic discovery & production. Natural products that form the basis of our current medical arsenal are often difficult to synthesize, purify, or engineer. In recent years bioinformatically predicted...
-
PhD Studentship: Ticking Clocks, Thriving Crops: Developing Climate-Resilient Crops Through Circadian Biology
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Antony Dodd Climate change poses a significant threat to our food supply, but you can be part of the solution In this groundbreaking research project, we're investigating how plants adapt to changing seasons and temperatures, with a focus on ensuring robust crop production despite environmental challenges.You'll explore the...
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PhD Studentship: Epigenetic Profiling of Cereal Fungal Invaders
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be...
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PhD Studentship: New Tools for Old Foes: Developing a New Class of Antimicrobial Metallodrugs
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr Rianne Lord Bacterial infections are the second-leading cause of deaths globally, and whilst antibiotics have undoubtedly saved millions of lives, their extensive use, coupled with pathogen evolution has resulted in drastic increases in prevalence of antibiotic-resistant strains. Amongst these, Gram-negative pathogens pose the most...
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PhD Studentship: Ticking Clocks, Thriving Crops: Developing Climate-Resilient Crops Through Circadian Biology
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary supervisor - Professor Antony Dodd Climate change poses a significant threat to our food supply, but you can be part of the solution! In this groundbreaking research project, we're investigating how plants adapt to changing seasons and temperatures, with a focus on ensuring robust crop production despite environmental challenges. You’ll explore...
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PhD Studentship: New Tools for Old Foes: Developing a New Class of Antimicrobial Metallodrugs
Found in: beBee S GB - 2 weeks ago
Norwich, United Kingdom University of East Anglia Full timePrimary Supervisor: Dr Rianne Lord Bacterial infections are the second-leading cause of deaths globally, and whilst antibiotics have undoubtedly saved millions of lives, their extensive use, coupled with pathogen evolution has resulted in drastic increases in prevalence of antibiotic-resistant strains. Amongst these, Gram-negative pathogens pose the...
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PhD Studentship: Controlling Greenhouse Gas Emissions by Targeting Bacterial G-quadruplex DNA/RNA Structures
Found in: beBee jobs GB - 2 weeks ago
Norwich, Norfolk, United Kingdom University of East Anglia Full timePrimary supervisor - Dr Andrew Gates As well as carbon dioxide (CO2), other important climate-active gases are known to drive global warming. Importantly, nitrous oxide (N2O), is the third most abundant greenhouse gas with 300-times greater global warming power than CO2 and it also contributes to the destruction of the ozone layer. Production of N2O is a...