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Senior Scientist I, Research

3 months ago

Oxford, United Kingdom Immunocore Full time

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

To validate novel therapeutic targets, contributing to their nomination onto portfolio and advance new pipeline programmes as a member of project teams. Frequently working in ambiguous situations, using new ideas and knowledge with increasing frequency.

KEY RESPONSIBILITIES

* Analyse expression of the most promising cancer targets on mRNA and protein level, contribute to their nomination onto portfolio and their progression towards IND
* Analyse expression of AML cancer targets across molecular subtypes and normal tissues
* Build a deep understanding of AML disease biology and awareness of key opinion leaders in the field
* Evaluate most representative models of cancer/ healthy tissues and, using in vitro ImmTAC assays, further elucidate target biology
* Enhance our target identification and validation processes with novel and innovative suggestions
* Analyse relevant literature to aid triaging potential cancer targets by gaining in-depth understanding of the target biological role and cancer disease biology
* Collaborate cross-functionally and act as a representative in cross-functional project teams
* Analyse and report experimental results verbally and in writing, and contribute to writing research publications

Other

The incumbent will be expected possesses strong working knowledge in their discipline to solve day-to-day problems and to be developing expertise outside of their area.

PERSON SPECIFICATION

Experience & knowledge

Essential
* Understanding of the drug discovery process
* Excellent oral and written communication skills
* Demonstrated record of scientific accomplishment as evidenced by publications, presentations, patent applications, and/or contributions to regulatory submissions
* Astute scientific approach with strong time management and agile work practices
* Experience with histology techniques, such as FFPE/ frozen tissue sectioning and Immunohistochemistry
* Experience with molecular biology techniques including primer design and qPCR, western blotting
* Experience with cell-based assays including cell culture, flow cytometry and FACS, in vitro immunoassays (ideally expertise with primary AML)

Desirable

* Experience in single/multiplex Immunofluorescence/ IHC/ In Situ Hybridisation
* In-depth knowledge of AML disease biology, molecular heterogeneity, stem cell biology and representative models
* Drug-hunting industry record
* Experience with analysis of single-cell RNA sequencing data (10x), bioinformatics, pathology training and complex cell and 3D models

Education & qualifications

* Normally requires a PhD in a scientific discipline and a minimum of 2-5 years related experience; may include post-doctoral experience.
* MSc degree or BSc degree with role-specific equivalent research or industrial experience.