Senior Research Scientist

4 weeks ago


Oxford, Oxfordshire, United Kingdom Northreach Full time

Job Title: Senior Research Scientist

Job Description:

We are seeking a highly skilled Senior Research Scientist to join our team at Northreach. As a key member of our cell engineering group, you will be responsible for leading and executing in vitro potency assays and functional assays to evaluate and enhance the sensitivity of engineered CARs and TCRs against specific targets.

Responsibilities:

  • Design and conduct complex preclinical studies, optimizing protocols for TCR-T and CAR-T cell development.
  • Perform high-throughput screening, cellular proliferation, and cytotoxicity assays to validate efficacy and specificity of TCR-T/CAR-T candidates.
  • Analyze and interpret complex data, generating insights to guide further engineering efforts and ensure product quality.
  • Collaborate closely with cross-functional teams in cell engineering, bioinformatics, and translational research.
  • Stay abreast of recent advances in T-cell engineering and immuno-oncology, contributing innovative ideas to the strategic R&D roadmap.

Requirements:

  • Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field, with 3+ years of relevant biotech or pharma experience; MSc with significant biotech experience may also be considered.
  • Hands-on experience with CAR-T or TCR-T cell development, ideally in preclinical settings within biotech or start-up environments.
  • Expertise in in vitro potency assays, functional assays, cytotoxicity, and cytokine release assays.
  • Proficiency in flow cytometry, immunophenotyping, and other cell-based assays to characterize engineered T cells.
  • Demonstrated ability to work independently, interpret complex data, and generate actionable insights.
  • Collaborative mindset, excellent communication skills, and ability to thrive in a dynamic start-up environment.

Northreach is an equal opportunity employer and we do not discriminate against any employee or applicant for employment based on race, colour, religion, sex, national origin, disability, or age. We are committed to promoting diversity, equity, and inclusion in the workplace and hiring practices, therefore only partner with business that promote DEI. We strive to create a welcoming and inclusive environment for all employees.



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