Clinical Research Fellow

2 weeks ago

Glasgow, United Kingdom University of Glasgow Full time

**Job Purpose**
This role will allow the development and implementation of clinical research skills and production of data which the postholder should use to develop a research thesis leading to an MD or PhD degree. Key roles will include being a team-member to support and maintain the development of the study documents for regulatory approval and the patient-facing activities i.e., screening, enrolment, and safety and efficacy data collection, CT imaging analyses. Although research will form the major component of this post, participation in associated clinical duties and a small amount of teaching will be incorporated into the role. Postholder will be expected to register and undertake research during the course of the project that will lead to a higher degree [MD/PhD].

**Main Duties and Responsibilities**
1. Plan, design and implement projects or parts of projects, in conjunction with collaborators and grant holders as appropriate in order to secure further funding to continue research that leads to a higher degree [MD/PhD].
3. Manage data handling and interpretation of research results and contribute to writing papers for publication in appropriate peer-reviewed journals.
4. Contribute to patient-facing clinical research activities in this project including screening, obtaining informed consent and study visits.
5. Collaborate with colleagues and participate in analysis of source data e.g. CT scans, safety data, team meetings/discussions and departmental research group activities.
6. Present work at internal and external seminars and national/ international conferences as appropriate to enhance the profile of the research group.
7. To deliver teaching materials and supervise undergraduate/postgraduate student projects and contribute to the academic progress of students
8. Contribute to the organisation of project-related workshops, seminars or conferences.
9. Undertake some clinical work under an NHS honorary contract as detailed below.
10. To contribute to the enhancement of the University’s international profile in line with the University’s Strategic Plan Inspiring People, Changing the World.

**Knowledge / Qualifications**

**Essential**:

A1. MBChB or equivalent.
A3. MRCP or FRCS
A4. Specialty experience in Cardiology or Cardiac Surgery

**Desirable**:

B1. BSc or equivalent intercalated degree.
B2. Evidence of distinction in career to date e.g. prizes, awards, bursaries.

**Skills and Experience**

**Essential**:

C1. Strong interpersonal skills and ability to work collegially to achieve a common goal/ School objective
C2. Prior experience in clinical research evidenced by abstract presentations and/or publications
C3. Evidence of prior experience in imaging with CT coronary angiography
C4. Good organisational including the ability to manage research projects.
C5. Excellent communication both oral and written

**Summary**
Patients who undergo coronary artery bypass (CABG) surgery commonly experience angina and/or myocardial infarction within 10 years of surgery. The main reason is occlusive saphenous vein graft disease. PROTECT (randomised double blind Placebo-contROlled Trial of AdTIMP3 to prEvent Coronary artery bypass grafT failure) is a first-in-human advanced (gene) therapy clinical trial programme to prevent failure of coronary artery bypass grafting using autologous saphenous vein.
Scientists in our team have developed a gene therapy via adenoviral-mediated over-expression of “tissue inhibitor of metalloproteinases-3 (TIMP-3)” which has been shown to reduce neointima formation in human saphenous vein ex vivo and in short (28 day) and longer term (3 months) pig vein grafts in vivo. Our team has developed AdTIMP-3 according to Good Manufacturing Practice (GMP) standards and this therapy has been assessed in pre-clinical pig study. The next phase is clinical, including a phase I first-in-human study (n=12 patients) followed by a phase 2 randomised controlled trial in approximately 120 patients to assess the safety and efficacy of this novel therapy in patients undergoing CABG surgery. This is a bench-to-bedside academic collaboration from the University of Glasgow, NHS Greater Glasgow and Clyde Health Board (Co-sponsors) and the NHS Golden Jubilee hospital. This research programme is funded by the Medical Research Council and the British Heart Foundation.

**General Information**
Clinical Research Fellowships offer medical graduates the opportunity for training in a range of research methodologies relevant to modern biomedical research in Medicine and related specialities. Most Clinical Fellows will undertake research training to consolidate career prospects, by participating in relevant research, which will usually form part of a further qualification or Higher degree [MSc, MD, PhD]. If further funding can be obtained, registration for an MD will be strongly encouraged and the research will be planned with successful attainment of a degree in mind. The post should make individuals co

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