Senior Scientist

4 weeks ago


Didcot, Oxfordshire, United Kingdom Etcembly Ltd Full time

About Etcembly Ltd

We are a next-generation TCR design and engineering company at the intersection of machine learning and drug development. Our team is passionate about revolutionizing the biotech industry through cutting-edge AI technologies, with a strong emphasis on computational protein engineering.

Job Summary

We are seeking a highly motivated and experienced Senior Scientist to join our team. The successful candidate will leverage their expertise in molecular biology and display technology platforms to test and characterize novel TCR molecules as potential drug candidates, and to generate training datasets for our proprietary machine learning models.

Key Responsibilities

  • Employ in vitro display techniques for high-throughput library screening, using guidance from experimental and computational data.
  • Develop tailored biochemical screening assays for specific applications.
  • Establish a robust workflow for TCR profiling, including potency and specificity screening methods.
  • Participate in scientific strategy planning and contribute to new ideas.
  • Document experimental data and effectively communicate scientific results through reports and presentations.
  • Troubleshoot experiments with minimal supervision and propose strategies to progress ongoing projects.
  • Follow and write protocols and SOPs.
  • Keep up to date with the scientific literature and developments in the field.

Requirements

  • PhD in a relevant discipline with postdoctoral experience and/or relevant industrial research experience (e.g. in biologics development), or an MSc with comparable experience.
  • Strong molecular biology experience, including proficiency in library generation and QC, Next-Generation Sequencing techniques, and variant screening/selection methods.
  • Proven expertise in at least one protein display method (e.g. phage, yeast, mammalian).
  • Demonstrable experience in leading and advancing projects.
  • Adaptable mindset to be flexible in the face of evolving priorities.
  • A highly motivated and proactive individual who is invested in the success of the team.
  • Excellent verbal and written communication skills.
  • Ability to work independently and in a collaborative team.

What We Offer

  • Opportunity to work at the cutting edge of AI and protein engineering, shaping the future of drug discovery and biotechnology.
  • Competitive salary and equity package.
  • State-of-the-art computational resources and access to cutting-edge biological datasets.
  • Collaborative and innovative work environment.
  • Opportunities for continued learning and professional development.
  • Based at Harwell Campus with a comprehensive benefits package.


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