Scientist - T Cell Engineer
3 weeks ago
We are seeking a highly skilled Scientist to join our Discovery Research team at a biotechnology start-up developing a synthetic biology platform for in vivo cell engineering. The successful candidate will be responsible for designing and implementing novel strategies for delivering genetic algorithms to cells, with a focus on treating genetic diseases, autoimmune disorders, and cancer.
Key Responsibilities:- Design and execute a wide range of experiments, technical studies, and tasks, working independently based on protocols and in line with departmental objectives.
- Assay engineered delivery vehicles using flow cytometry, western blot, ELISA, and immunofluorescence.
- Develop novel genetic constructs for use in T Cell engineering and implement their design.
- Develop robust T Cell engineering platforms for quantifying delivery vehicle potency and T Cell functionality assays to determine their functionality and efficacy post-engineering.
- Liaise with programme leaders and matrix team members for data exchange and cell culture/experimental planning.
- Timely, accurate recording and analysis of results and compliance with data integrity procedures.
- Timely presentation of data to the department and wider company.
- Contribution to critical interpretation of data to draw results-driven hypotheses, with influence on project/function direction.
- PhD with experience in T Cell biology (or equivalent experience gained in industry).
- Knowledge of T Cell differentiation, subtypes, transcription factors involved, and their relevance to function.
- Experience handling and culturing a range of cell lines.
- Experience with lentiviral vector design, production, and transduction of T Cells.
- Preferably, experience with CRISPR-based editing of primary human T Cells, both KO and KI.
- Experience with genetic approaches for quantifying T Cell engineering outcomes.
- Experience with assays of T Cell functionality and potency, especially in the context of CAR-T.
- Strong experience with flow cytometry-based assays.
- Experience with single-cell sequencing assays would be a benefit.
- Fluency in spoken and written English.
- Meticulous in record keeping, and able to keep track of and co-ordinate large numbers of ongoing projects.
Northreach is an equal opportunity employer and we do not discriminate against any employee or applicant for employment based on race, colour, religion, sex, national origin, disability, or age. We are committed to promoting diversity, equity, and inclusion in the workplace and hiring practices, therefore only partner with businesses that promote DEI. We strive to create a welcoming and inclusive environment for all employees.
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