Scientist (T Cell Engineering)

1 month ago

Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time
Job Title: Scientist (T Cell Engineering)

Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.

Job Summary:

We are looking for a talented scientist to design and implement novel strategies for delivering complex genetic payloads to T Cells in vivo. The successful candidate will have a strong background in T Cell biology and experience with lentiviral vector design, production, and transduction of T Cells.

Key Responsibilities:
  • Design and implement novel genetic constructs for use in T Cell engineering
  • Develop robust T Cell engineering platforms for the quantification of delivery vehicle potency
  • Develop T Cell functionality assays to determine their functionality and efficacy post-engineering
  • Assay engineered delivery vehicles using flow cytometry, western blot, ELISA, and immunofluorescence
  • Liaise with programme leaders and matrix team members for data exchange and cell culture/experimental planning
Requirements:
  • PhD with experience in T Cell biology (or equivalent experience gained in industry)
  • Knowledge of T Cell differentiation, subtypes, transcription factors involved, and their relevance to function
  • Experience handling and culturing a range of cell lines
  • Experience with lentiviral vector design, production, and transduction of T Cells
  • Preferably, experience with CRISPR-based editing of primary human T Cells, both KO and KI
  • Experience with genetic approaches for quantifying T Cell engineering outcomes
  • Experience with assays of T Cell functionality and potency, especially in the context of CAR-T
  • Strong experience with flow cytometry-based assays
  • Fluency in spoken and written English
What We Offer:

Xap Therapeutics offers a dynamic and innovative work environment, with opportunities for professional growth and development. We are committed to fostering a culture of collaboration, creativity, and excellence.

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