Scientist (T Cell Engineering)

1 month ago

Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time
Job Title: Scientist (T Cell Engineering)

Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.

Job Summary:

We are looking for a talented Scientist to advance our platform's ability to deliver complex genetic payloads to T Cells in vivo. The successful candidate will be responsible for designing and implementing novel strategies for gene medicine delivery, as well as developing assays to determine the phenotype, efficacy, and potency of engineered T Cells.

Key Responsibilities:
  • Design and execute experiments to advance our gene medicine delivery platform
  • Develop and implement novel genetic constructs for T Cell engineering
  • Assay engineered delivery vehicles using flow cytometry, western blot, ELISA, and immunofluorescence
  • Develop robust T Cell engineering platform for quantification of delivery vehicle potency
  • Develop T Cell functionality assays to determine their functionality and efficacy post-engineering
  • Liaise with programme leaders and matrix team members for data exchange and cell culture/experimental planning
Requirements:
  • PhD in T Cell biology or equivalent experience in industry
  • Experience with lentiviral vector design, production, and transduction of T Cells
  • Preferably, experience with CRISPR-based editing of primary human T Cells, both KO and KI
  • Strong experience with flow cytometry-based assays
  • Fluency in spoken and written English
What We Offer:

Xap Therapeutics offers a dynamic and fast-paced working environment, with opportunities for professional growth and development. We are committed to innovation and excellence, and we are looking for talented individuals who share our vision.

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