Scientist (T Cell Engineering)

1 month ago

Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time
Job Title: Scientist (T Cell Engineering)

Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.

Job Summary:

The successful candidate will be responsible for advancing our platform's ability to deliver complex genetic payloads to T Cells in vivo. This will involve designing and implementing novel strategies for gene medicine delivery, as well as developing novel assays to determine the phenotype, efficacy, and potency of these T Cells.

Key Responsibilities:
  • Planning and execution of experiments, technical studies, and tasks, working independently based on protocols and in line with departmental objectives.
  • Assaying of our engineered delivery vehicle using flow cytometry, western blot, ELISA, and immunofluorescence.
  • Design and implementation of novel genetic constructs for use in T Cell engineering.
  • Development of a robust T Cell engineering platform for the quantification of our delivery vehicles' potency.
  • Development of T Cell functionality assays to determine their functionality and efficacy post-engineering.
  • Cell culture (propagation, banking, characterization) of cell lines and primary cells.
  • Liaise with programme leaders and matrix team members for data exchange and cell culture/experimental planning.
  • Timely, accurate recording and analysis of results and compliance with data integrity procedures.
  • Timely presentation of data to the department and wider company.
  • Contribution to critical interpretation of data to draw results-driven hypotheses, with influence on project/function direction.
Requirements:
  • A PhD with experience in T Cell biology (or equivalent experience gained in industry).
  • Knowledge of T Cell differentiation, subtypes, transcription factors involved, and their relevance to function.
  • Experience handling and culturing a range of cell lines.
  • Experience with lentiviral vector design, production, and transduction of T Cells.
  • Preferably, experience with CRISPR-based editing of primary human T Cells, both KO and KI.
  • Experience with genetic approaches for quantifying T Cell engineering outcomes.
  • Experience with assays of T Cell functionality and potency, especially in the context of CAR-T.
  • Strong experience with flow cytometry-based assays.
  • Experience with single-cell sequencing assay would be a benefit.
  • Fluency in spoken and written English.
  • Meticulous in record keeping, and able to keep track of and coordinate large numbers of ongoing projects.

  • Scientist (T Cell Engineering)

    4 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented scientist to design and implement novel strategies for delivering...

  • Scientist (T Cell Engineering)

    4 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented scientist to design and implement novel strategies for delivering...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented scientist to design and implement novel strategies for delivering...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented scientist to design and implement novel strategies for delivering...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented Scientist to advance our platform's ability to deliver complex...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented Scientist to advance our platform's ability to deliver complex...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented scientist to join our team and contribute to the development of...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented scientist to join our team and contribute to the development of...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented Scientist to advance our platform's ability to deliver complex...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:We are looking for a talented Scientist to advance our platform's ability to deliver complex...

  • Scientist (T Cell Engineering)

    3 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:The successful candidate will be responsible for advancing our platform's ability to deliver...

  • Scientist (T Cell Engineering)

    3 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:The successful candidate will be responsible for advancing our platform's ability to deliver...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.About the Role:The successful candidate will be responsible for advancing our platform's ability to deliver...

  • Scientist (T Cell Engineering)

    1 month ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.About the Role:The successful candidate will be responsible for advancing our platform's ability to deliver...

  • Scientist (T Cell Engineering)

    4 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:The successful candidate will be responsible for advancing our platform's ability to deliver...

  • Scientist (T Cell Engineering)

    4 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    Job Title: Scientist (T Cell Engineering)Xap Therapeutics is a pioneering biotechnology company that is revolutionizing the field of synthetic biology. We are seeking a highly motivated Scientist - T Cell Engineering to join our Discovery Research team.Job Summary:The successful candidate will be responsible for advancing our platform's ability to deliver...

  • Scientist - T Cell Engineer

    3 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Northreach Full time

    Scientist - T Cell EngineeringWe are seeking a highly skilled Scientist to join our Discovery Research team at a biotechnology start-up developing a synthetic biology platform for in vivo cell engineering. The successful candidate will be responsible for designing and implementing novel strategies for delivering genetic algorithms to cells, with a focus on...

  • Scientist - T Cell Engineer

    3 weeks ago

    Cambridge, Cambridgeshire, United Kingdom Northreach Full time

    Scientist - T Cell EngineeringWe are seeking a highly skilled Scientist to join our Discovery Research team at a biotechnology start-up developing a synthetic biology platform for in vivo cell engineering. The successful candidate will be responsible for designing and implementing novel strategies for delivering genetic algorithms to cells, with a focus on...

  • Scientist (T Cell Engineering) - T Cell Therapies Specialist

    2 months ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    About Xap TherapeuticsXap Therapeutics is a pioneering biotechnology company dedicated to developing innovative, synthetic biology-driven platforms for in vivo cell engineering. Our mission is to revolutionize the delivery of complex genetic algorithms to cells, enabling the treatment of genetic diseases and autoimmune and cancer conditions.Job SummaryWe are...

  • Scientist (T Cell Engineering) - T Cell Therapies Specialist

    2 months ago

    Cambridge, Cambridgeshire, United Kingdom Xap Therapeutics Full time

    About Xap TherapeuticsXap Therapeutics is a pioneering biotechnology company dedicated to developing innovative, synthetic biology-driven platforms for in vivo cell engineering. Our mission is to revolutionize the delivery of complex genetic algorithms to cells, enabling the treatment of genetic diseases and autoimmune and cancer conditions.Job SummaryWe are...