Research Scientist

4 days ago


York, York City, United Kingdom University of York Full time

Are you a highly motivated researcher looking to advance your career in molecular biology? We have an exciting opportunity for a Postdoctoral Research Associate at the University of York.

About the Role

We are seeking a skilled researcher to join our team and contribute to a project investigating the signalling pathways that regulate autophagy, lysosome exocytosis, and biomolecular condensates during the lifecycle differentiations and host adaptation of the African trypanosome T. brucei.

The successful candidate will be responsible for validating a high-throughput live imaging system combined with gene silencing screens of protein kinases, as well as performing autophagy-related proximity labelling, phospho-proteomic, and mass spectrometry analysis.

The post requires a PhD in Molecular Biology, Cell Biology, or Microbiology, and knowledge of standard molecular biology techniques, -omics studies, and imaging techniques. Experience in handling murine models and pathogens, protein kinases, -omics data analysis, super-resolution microscopy, live imaging, and CRISPR/Cas9-mediated precision editing is highly desirable.

Key Responsibilities
  • Validate high-throughput live imaging system combined with gene silencing screen of protein kinases
  • Autophagy-related proximity labelling, phospho-proteomic, and mass spectrometry analysis
  • Assays of protein interaction and enzyme activity using biophysical and biochemical approaches
  • Generation of mutated cell lines by CRISPR/Cas9-mediated precision editing and phenotypic validation in vitro and in murine model
  • Biomolecular condensate purification and component analysis by mass spectrometry and sequencing
Requirements
  • PhD in Molecular Biology, Cell Biology, or Microbiology
  • Knowledge of molecular biology, parasitology, and modern techniques
  • Skills and experiences in cell culture, handling of class 2 pathogens, murine infection, and gene editing
  • Excellent track record of research publications and developed communication skills
  • Attention to detail, collaborative ethos, and willingness to work proactively
What We Offer

We offer a competitive salary of £32,000 - £38,000 per annum, depending on experience, as well as excellent benefits including family-friendly, flexible working arrangements, and inclusive facilities.



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