Senior Research Scientist

2 weeks ago

London, Greater London, United Kingdom Imperial College London Full time

Imperial College London is seeking a highly motivated and talented postdoctoral researcher with a strong background in molecular biology to join the Martinez-Sanchez research group for a collaborative project with the Srivastava group at Imperial College London and the Rodriguez-Calvo lab at Helmholtz Munich.

This innovative project aims to investigate microRNA heterogeneity within pancreatic beta-cell subpopulations at single-cell resolution to improve beta-cell therapies for type 1 diabetes. The project is funded by Diabetes UK and aims to develop novel therapeutics for type 1 diabetes.

As a postdoctoral researcher, you will use cutting-edge molecular, computational, and imaging techniques to explore and compare miRNA expression and targeting at high-throughput and single-cell levels between stem-cell-derived islets, human islets, and pancreatic tissue in health and T1D.

You will take the initiative in the planning of research, identify and develop suitable techniques and equipment for data collection and analysis, ensure data reliability, maintain accurate records, and write reports for submission to research sponsors and publications.

You will also participate in the training and supervision of junior team members.

By leading this project, you will provide novel understanding of the molecular mechanisms underlying the heterogeneous functionality of beta-cells, enhancing current efforts to preserve and generate beta-cells for T1D treatment.

  • PhD degree in Molecular and Cellular Biology or a related discipline is required.
  • Strong experience in developing and/or applying advanced molecular biology techniques is essential.
  • Previous experience in sequencing library preparation (.small RNA-seq or RNA-seq) and single-cell libraries is highly advantageous.
  • Practical experience with cell culture is essential, and iPSC culture/differentiation experience is desirable.
  • Computational transcriptomics experience is advantageous, with single-cell experience preferred.
  • Previous experience in beta-cell and/or miRNA biology is advantageous.
  • Practical experience in pathology, staining, microscopy, and image analysis is a plus.
  • Familiarity with computer programming is desirable.
  • Excellent communication and problem-solving skills are essential.
  • Ability to work as part of a team and contribute to team supervision is essential.

Our laboratory is committed to mentoring scientists and fostering creative thinking and scientific independence. This position will provide opportunities to develop cutting-edge research skills, communication, leadership, and management skills.

We offer:

  • Opportunities to expand molecular biology skills and develop experimental skills in single-cell analysis of small RNA expression and action.
  • Development of skills in beta-cell and microRNA biology and expansion of knowledge in islet function in health and diabetes.
  • A chance to develop computational skills in single-cell omics.
  • Training in cutting-edge microscopy and image analysis to study small RNA expression in the human pancreas.
  • The opportunity to advance your career at a world-leading institution and contribute to our mission to continue science for humanity.
  • The opportunity to work with multiple teams in the UK and Germany.
  • Access to Imperial's sector-leading training opportunities and career progression.
  • A competitive salary and remuneration package, including 39 days off per year and generous pension schemes.

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