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Senior RNA Translation Specialist
1 month ago
We are seeking a highly skilled Senior Scientist to join our US Programs Biology team at Serna Bio, a preclinical drug discovery company developing small molecules that modulate translation and splicing by targeting RNA.
About the PositionThis is an exciting opportunity to lead the expansion and advancement of our therapeutic pipeline by bringing your experiment design and CRO management skills to target selection, drug discovery/development, and early clinical work.
Key Responsibilities- Drive the development and execution of hit-to-lead and lead optimisation of core drug discovery programs
- Work closely with the platform team to ensure the programs are being supported by, and feeding into, the Serna Bio ChemAI Platform
- Design the strategy, data, and statistical design process for assays for hit to lead and lead ops, leaning on previous experience leading drug discovery program progression
Our ideal candidate will have a PhD in molecular biology or a related field, plus at least 4 years of industry experience in hit to lead, and lead optimisation for drug discovery programs.
Technical Requirements- PhD in molecular biology or a related field, Post Doc / plus at least 4 years of industry experience in hit to lead, and lead optimisation for drug discovery programs.
- Specific experience in setting up key processes and milestones needed to move a program from hit ID to hit to lead and lead ops.
- Experience in assay design and setup for early-stage hit identification for drug discovery programs, and assay setup for robust SAR optimisation.
- Experience developing and running screening assays for hit-to-lead and lead optimisation.
- Demonstrable experience managing external collaborations and CROs.
- Experience in autoimmune, metabolic or neurological disorders.
- Demonstrated experience with vector design, cloning and fluorescence and luminescence assays, specifically when used in a high throughput system, or for hit to lead or lead optimisation.
- Experience leading and prioritising among multiple projects and efficiently advancing projects to Proof of Concept and no-go decisions.
- Experience working in cross-functional and distributed teams.
- Ability to work under pressure, manage different projects and deliver to defined timelines.
- Excellent oral and written communication skills e.g. can tailor the complexity of communications as and when required, whilst maintaining clarity of communication.
We offer a competitive salary of $120,000 - $160,000 per year, depending on experience, plus benefits including health insurance, retirement plan, and paid time off.