Computational Chemistry Expert

9 hours ago


Cambridge, Cambridgeshire, United Kingdom Amphista Therapeutics Limited Full time

Amphista Therapeutics Limited Overview

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We are a pioneering company in the field of targeted protein degradation (TPD), with a mission to develop innovative medicines for severe diseases. Our proprietary degrader platform has shown promise in addressing the limitations of existing TPD strategies, and we are seeking an experienced Senior Principal Computational Chemist to join our growing team.

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About the Role

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The successful candidate will have a significant scientific leadership role within our Cheminformatics & Computational Chemistry team. You will utilise your extensive experience in computational chemistry, biomolecular structural analysis, and computational modelling techniques to advance our TPD drug programmes. Your contributions will directly impact multiple drug discovery projects, while also helping to grow our proprietary Amphista protein degrading platform.

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Key Responsibilities

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• Lead the computational chemistry support for multiple TPD drug programmes, working closely with fellow computational chemists, medicinal chemists, informaticians, and the project team

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• Gather, analyse, and report on biomolecular and ternary complex structural data to derive novel insights into SAR and TPD mechanisms

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• Build, evaluate, and deliver structure- and ligand-based models to advance our TPD projects, and support their use by project teams

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• Apply computer-aided drug design techniques to design targeted protein degraders, including virtual screening, bioisosteric replacements, scaffold hopping, linker design, MMPA, and de novo design

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Additional Responsibilities

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• Act as a key domain expert for computational chemistry and the handling of biomolecular data, consulting with scientific teams across the company

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• Maintain a comprehensive awareness of contemporary literature developments in computational drug discovery and medicinal chemistry, with particular attention to targeted protein degradation

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• Collaborate and communicate effectively with stakeholders, including chemists, structural biologists, bioinformaticians, and biologists

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What's on Offer

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A competitive salary of approximately £90,000 - £120,000 per annum, dependent on experience, plus benefits including flexible working hours, private medical insurance, life assurance, critical illness cover, health cash plan, discretionary bonus scheme, allocation of growth shares, pension scheme with employer matched contribution, and 25 days holiday plus bank holidays.

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Company Information

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Amphista Therapeutics Limited is a dynamic company operating at the cutting edge of protein degradation-based drug discovery. We are continuing to grow and are looking for a key hire to expand our screening and assay teams.

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Our team comprises highly experienced drug discovery and TPD experts across both biology and chemistry disciplines, creating an ideal learning environment to advance your scientific career development quickly. This is an exciting opportunity to join a fast-growing and dynamic company developing first-in-class medicines to treat cancer and other areas of high unmet medical need.



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