Postdoctoral Research Associate

3 weeks ago


York, York City, United Kingdom University of York Full time

Job Role: Postdoctoral Research Associate

Applications are invited for a postdoctoral research position to characterise the signalling pathways that regulate autophagy, lysosome exocytosis, and biomolecular condensates during the lifecycle differentiations and host adaptation of the African trypanosome T. brucei. The position is funded by a MRC Collaborative Doctoral Award to Dr. Mathieu Cayla, who will manage the post.

Key Responsibilities:

  1. Validate a high-throughput live imaging system combined with gene silencing screens of protein kinases.
  2. Autophagy-related proximity labelling, phospho-proteomic, and mass spectrometry analysis.
  3. Assays of protein interaction and enzyme activity using biophysical and biochemical approaches.
  4. Generation of mutated cell lines by CRISPR/Cas9 mediated precision editing and phenotypic validation in vitro and in murine models.
  5. Biomolecular condensate purification and component analysis by mass spectrometry and sequencing.

Requirements:

  1. A PhD in Molecular Biology, Cell Biology, or Microbiology.
  2. Knowledge in molecular biology, parasitology, and a range of modern techniques to engage in high-quality research.
  3. Skills and experiences in cell culture, handling of class 2 pathogens, murine infection, and gene editing are desirable.
  4. Excellent track record of research publications and highly developed communication skills.
  5. Attention to detail, collaborative ethos, and interest in co-supervising students.
  6. Positive attitude to colleagues and students, with a willingness to work proactively.
  7. Commitment to personal development and understanding of equality and diversity issues.


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