Senior Scientist, Cell Immunology Expert
2 weeks ago
We are seeking a highly motivated and skilled Cellular Immunologist to join our growing lab team at Baseimmune. As a core member of the Translational Research Team, you will be responsible for Cellular Immunology workflows and vaccine development.
This lab-based role requires a combination of scientific and technical expertise in the field of cell immunology and T cell biology, including MHC antigen processing and TCR function.
You will provide and apply your cellular immunology expertise to the design, validation, optimisation and execution of cell-based assays required to evaluate our innovative antigen design platforms and characterise T cell responses.
Key Responsibilities- Development of robust testing platforms to inform and validate antigen design for T cell responses, MHC I and MHC II-mediated presentation and vaccine design.
- To conceptualise, design, develop and execute T cell-based functionality assays using primary cells, cell lines, etc; to determine and characterise T cell activation and phenotype following immunisation as part of our preclinical evaluation pipeline.
- Cell culture (propagation, isolation, banking and characterisation) of cell lines and primary cells, including processing of immune tissues.
- Collaborating effectively with other functions within the Translational Research team to support and assist their research activities as needed.
- Maintain detailed records and analysis of experimental procedures, observations, and results in compliance with data integrity procedures and contribute to the preparation of study reports and presentations.
A PhD in T cell biology or cellular immunology with at least 2 years of relevant post-doctoral experience in academia and/or industry; OR a PhD in a relevant subject with equivalent T-cell experience gained in academia or industry post-PhD.
Hold a Home Office Personal Licence, PIL A-C with rodents OR willingness to obtain one and work with in vivo models.
Desired Qualifications and SkillsExperience in T cell biology, development and optimisation of analytical and functional cell-based assays to assess activation, potency, etc.
Experience in in vitro and ex vivo assays to assess cellular immune responses in human and/or animal T cells, including IFN-γ ELISpots, cytokine production, cell expansion, intracellular cytokine staining (ICS) and CTL assays.
Experience with handling, manipulation, and characterisation of T cells (primary, cell lines, IPSC-derived).
Experience with high-parameter flow cytometry based-assays.
Leadership and Soft Skills: Team-oriented personality, able to build strong relationships in a diverse environment, work effectively as part of a collaborative team, but also execute tasks independently when needed.
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