PhD Research Scientist

2 days ago

Oxford, Oxfordshire, United Kingdom ZipRecruiter Full time
Job Title: PhD Research Scientist

We are seeking a highly motivated and experienced PhD Research Scientist to join our Cell Biology team. As a key member of our team, you will be responsible for designing and troubleshooting assays to examine the binding of TCR bispecific molecules to cells, the activation of T cells, and T-cell mediated killing.

Key Responsibilities:

  • Design and conduct experimental work to align with company priorities and meet scientific timelines.
  • Collaborate effectively with other research functions, such as Protein Engineering and CMC teams, to guide optimisation and development of soluble TCRs.
  • Dissect molecular mechanisms of T cell activation and T cell mediated killing by soluble TCR bispecific molecules.
  • Drive innovation and continuous improvement within the Cell Biology team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process.
  • Present scientific findings and summary conclusions to your department, project team, and company leadership team.

Requirements:

  • Familiarity with a range of cell and molecular biology techniques, such as flow cytometry analysis, T cell assays, killing assays, cytokine assays, designing and executing recombinant DNA sub-cloning strategies, making lentiviral supernatants, lentiviral transduction.
  • Direct hands-on laboratory experience in testing and developing of biologics, including the assessment of the biological impact of their engagement with therapeutic targets.
  • Experience leading projects, overseeing the experimental strategy, and coordinating the work of other team members.
  • A PhD in a relevant biological subject with or without post-doctoral experience in academia and/or with substantial subsequent biotechnology or pharmaceutical industry experience in R&D teams.
  • Ability to independently lead programmes to advance the company's goals, review competing priorities, and recommend strategies to advance the programme.
  • Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
  • Strong communication skills with the confidence and judgement to challenge appropriately.
  • Demonstrable problem-solving ability, creative thinking, and be pro-active in driving the project forwards.

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