Human Genetics Consultant

3 weeks ago


London, Greater London, United Kingdom Novo Nordisk AS Full time

Position Overview

We are seeking a highly skilled and innovative Genomic Precision Medicine Specialist to leverage advanced human genetics insights aimed at enhancing trial outcomes and fostering genetics-driven precision medicine for obesity management.

In this role, you will:

  • Provide genetic expertise to project teams focused on advancing specific therapies through the drug development pipeline,
  • Collaborate closely with colleagues to pinpoint opportunities where genetics can inform strategic decisions, such as indication selection, target population identification, and understanding adverse effects,
  • Integrate genetic data with other omics disciplines—proteomics, metabolomics, transcriptomics, and epigenetics—to deepen our understanding and tailor treatment responses,
  • Be encouraged to merge trial data with genetic insights to guide decision-making and identify populations most likely to benefit from the treatments developed by our scientists.

You will be expected to initiate and lead your own projects while also contributing your expertise to ongoing initiatives within the Human Genetics Centre of Excellence (CoE). Our research center thrives on collaboration, and you will work alongside statistical geneticists, clinicians, and computational and laboratory scientists from various disciplines, as well as external partners, to ensure optimal treatment delivery to patients.

We provide a hybrid working model, allowing for flexibility with three days spent in one of our offices.

Qualifications

We invite candidates who possess a strong team-oriented mindset, attention to detail, and a passion for thriving in a dynamic, fast-paced environment where creative independence and knowledge sharing are highly valued. A keen interest in applying your expertise within the realm of drug development is essential.

We are particularly eager to connect with candidates who have a background in human genetics applied to drug discovery or development, enhancing our precision medicine initiatives.

Ideal candidates will:

  • Hold a Ph.D. in human genetics, statistical genetics, genetic epidemiology, pharmacogenomics, or related fields, with notable contributions to high-impact scientific literature.
  • Have several years of post-PhD experience focusing on the genetics of obesity.
  • Demonstrate proficiency with high-performance computing systems and programming languages for analyzing large-scale datasets, such as R, Python, or similar.
  • Have experience working with extensive genetic datasets and GWAS methodologies, including polygenic risk scores, marker-trait and gene-trait associations, PheWAS, Mendelian Randomization, and co-localization analyses.
  • Exhibit strong communication skills, capable of conveying insights and concepts to diverse audiences.
  • Be self-motivated and excel in interdisciplinary team settings.

Previous experience handling omics data (e.g., transcriptomics, proteomics) will be considered advantageous, as will professional or postdoctoral experience in managing and analyzing clinical trial data within academia or the biotech/pharmaceutical industry.

About the Department

You will join our Translational Genomics & Precision Medicine Department, part of the Human Genetics Centre of Excellence (CoE). The CoE, led by Vice President Joanna Howson, PhD, focuses on utilizing data science and human genetics to discover and develop novel drug targets and biomarkers through various human-centric approaches, including high-throughput genetic discovery screens, Mendelian randomization, and precision medicine strategies relevant to type 2 diabetes, chronic kidney disease, cardiovascular disease, non-alcoholic steatohepatitis (NASH), obesity, and rare endocrine and blood disorders.

The CoE is integrated within the newly established Digital Science & Innovation (DSI) organization, which supports the digital transformation across all therapy areas in Research & Early Development. In DSI, we collaborate in multidisciplinary teams across all areas of R&ED and R&ED IT, engaging in drug development projects from early discovery to pre-clinical stages. We also pursue external collaborations to access the latest research and technological advancements, automate our laboratories and processes, and focus on nurturing and retaining top talent.



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