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Director of Quantitative Biomarkers
2 months ago
Exscientia is a pioneering AI-driven precision medicine company dedicated to revolutionizing the discovery, design, and development of innovative drugs. Our cutting-edge platform enables us to rapidly identify and validate promising therapeutic targets, accelerating the development of life-changing medicines.
The RoleWe are seeking a highly skilled Director, Quantitative Biomarkers to lead our preclinical and clinical translational research programs in oncology. As a key member of our team, you will be responsible for designing, implementing, and interpreting biomarker strategies that support early clinical programs. Your expertise will be instrumental in defining pharmacodynamic markers to support proof of mechanism determination and informing indication and dosing regimen selection.
This is a hybrid role, requiring occasional travel to our offices in Oxford, UK (approximately once per quarter), with flexibility to work from home in the UK the remaining time. We offer a collaborative and intellectually stimulating environment, with opportunities for professional growth and development.
Key Responsibilities- Develop and deliver clinical biomarker strategies for preclinical and clinical assets, participating in compound development teams and leading pertinent working groups.
- Analyze, interpret, and present emerging clinical biomarker data, working closely with quantitative clinical pharmacology to support model-informed drug development for clinical programs.
- Contribute to building scientific rationale to support the clinical strategy, working closely across groups and functions to explore novel indications, targeted patient populations, and new drug combinations for compounds in research, preclinical, and clinical development.
- Regularly report biomarker data to project teams, line management, and other senior governance groups as necessary.
- Fulfill regulatory responsibilities, including preparing, updating, and finalizing the biomarker sections in clinical protocols, Investigator Brochures, Clinical Study Reports, and compound development plans.
- Contribute to the generation of preclinical experimental plans to support the clinical biomarker strategy, supervise studies, and integrate into clinical development plans.
- Interact and liaise with internal experts, external experts, academic groups, and CROs to establish collaborations and projects.
- MSc, PhD, or PharmD in immuno-oncology, tumor biology, or a related field.
- 10+ years of experience conducting quantitative biomarker/translational biology research in a pharmaceutical/biotech setting, including 3+ years of clinical trial experience.
- Experience in designing and executing preclinical research, in-vitro and in-vivo pharmacology, and mechanism of action studies.
- Leadership experience in drug discovery/development, representing clinical BTB research on project teams and communicating goals and deliverables to senior management and governance committees.
- Ability to work effectively on multiple oncology programs in a fast-paced environment, with resilience and adaptability to changes in priorities.
- Strong collaboration and teamwork skills, with excellent written and verbal communication.
- A competitive salary and bonus structure.
- A comprehensive benefits package, including private health insurance, dental, and vision benefits.
- A generous 28-day holiday allowance, plus public holidays, with flexibility to carry over or purchase extra holidays.
- A flexible working environment, with opportunities for remote work and a four-week paid sabbatical after four years of service.
- A commitment to diversity, equity, and inclusion, with a focus on creating a welcoming and inclusive environment for all employees.
