Postdoctoral Researcher in Pharmacometrics

3 days ago

Bracknell, United Kingdom CK Group- Science, Clinical And Technical Full time
Postdoctoral Researcher (Global PK/PD and Pharmacometrics) Role

The successful candidate will play a key role in high-impact research endeavours spanning from discovery to advanced clinical development of Antibody Drug conjugates (ADC). Key responsibilities include establishing the appropriate dose and regimen to achieve better therapeutic index and understanding preliminary dosing requirements.

Additionally, the researcher will establish a comprehensive and flexible framework (Clinical Utility Index) for modelling ADC PKPD and the Exposure-Response relationship in both preclinical and clinical settings.

Develop a cellular mathematical model with a deep understanding of physiochemical properties, the range of affinities that are compatible with the target product profile for each ADC target, and the mechanism of action of ADC components (m Ab, linker and payload and conjugated ADCs).

Your Background

PhD in Pharmacometrics, Pharmaceutical/Biomedical Sciences, Computational Sciences, Engineering, or a related discipline.

Experience using relevant software such as R, Monolix, NONMEM, MATLAB, or similar.

Experience in QSP, PK/PD, exposure-response modeling or other modelling & simulation related discipline.

Understanding of pharmacokinetics and/or pharmacodynamic principles.

Proficient in data analysis and reporting.

Company

Our client is one of the largest pharmaceutical companies in the world, focusing on finding answers for some of the world's most urgent medical needs.

Location

This role is based at our client's site in Bracknell, with a hybrid work arrangement requiring office presence two times per week.

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