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Principal Bioinformatics Scientist
2 months ago
Northreach is a dynamic recruitment agency that connects businesses with top talent in the Advanced Therapies sector. Our mission is to provide a seamless and personalized recruitment experience for clients and candidates, and to create a positive work environment that encourages equality, innovation, and professional growth.
**Company Profile**
Our client is a pioneering biotechnology company that specializes in the development of innovative therapies for various diseases. They have a strong focus on research and development, with a team of experts working together to advance the field of antigen modulation.
**Job Summary**
We are seeking a highly skilled Senior Bioinformatics Specialist to join our client's team. The successful candidate will play a key role in the conceptualization, design, and implementation of innovative data analysis strategies to advance the company's ERAP1 inhibitor-driven antigen discovery pipeline.
**Key Responsibilities**
- Contribute to the development and maintenance of high-quality bioinformatics pipelines for processing large-scale mass spectrometry data.
- Define objectives and perform statistical analysis of data-dependent (DDA) and data-independent (DIA) immunopeptidomics assays.
- Conduct analysis of parallel reaction monitoring (PRM) peptide assays.
- Integrate antigen discovery workflows with transcriptomic and genomic data.
- Leverage external resources and databases to enhance internal workflows and improve target prioritization.
- Stay at the forefront of scientific advances in mass spectrometry-based immunopeptidomics and antigen presentation, including software and new methodologies.
- Lead and manage analytical aspects of projects, including data preparation, analysis, and visualization.
- Provide data-driven insights to inform experimental design.
- Communicate research findings to both technical and non-technical audiences, internally and externally.
**Requirements**
- PhD (or equivalent experience) in bioinformatics, immunology, computational biology, or a related field.
- In-depth knowledge of mass spectrometry-based proteomics data acquisition and processing, with familiarity in data-dependent and data-independent methods preferred.
- Strong knowledge of machine learning and/or multivariate statistical modeling.
- Proficiency in statistical programming and building statistical models.
- Expertise in R or Python programming.
- Extensive experience in large-scale bioinformatics analysis of omics data.
- Proficient in Linux OS and shell scripting.
- Experience with building and running analytical pipelines using NextFlow and Docker.
- Ability to analyze, interpret, and record findings efficiently and in compliance with standards.
- Strong communication skills, capable of conveying complex topics to diverse audiences.
- Proven success working in multidisciplinary scientific teams (desirable).
- Familiarity with cloud infrastructure (e.g., AWS) is a plus.
- Deep understanding of antigen processing (desirable).
- Prior research experience in an industrial setting (desirable).
- Knowledge of molecular biology, cell biology, or immunology (desirable).
**What We Offer**
Our client offers a dynamic and collaborative work environment, with opportunities for professional growth and development. They are committed to promoting diversity, equity, and inclusion in the workplace and hiring practices, and strive to create a welcoming and inclusive environment for all employees.
