Bioinformatician - Haniffa Group

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.

**About the role**:
The Haniffa lab is seeking a Bioinformatician to support single cell and spatial transcriptomic studies. The role will support computational projects in the lab, studying healthy and diseased skin and human development.

The primary focus will be the analysis of a large atopic eczema patient cohort that includes single-cell, multi-omic and spatial genomic datasets before and after treatment.

This position is for a 3 year fixed term contract.

**About us**:
The Haniffa lab is a leader in the international Human Cell Atlas initiative to systematically map all cells in the body and across the lifespan. Our lab applies disruptive omics technologies to study human cells at single-cell resolution. We make use of state-of-the-art single cell technologies, to understand how the immune system develops and maintains health, and study the consequences of infection, inflammation and disease. We provide a multifaceted computing infrastructure including a powerful LSF cluster, GPU access, an OpenStack cloud architecture, and easy access to interactive notebooks for convenient day-to-day data analysis.

The team is a diverse mixture of wet and dry lab researchers and clinicians. The lab collaborates closely with leading computational biology teams in single cell and spatial biology including Sarah Teichmann, Fabian Theis and Mohammad Lotfollahi.

**Key responsibilities of the role**:
This is an exciting opportunity to work in single cell and spatial genomics to understand how the immune system develops and maintains health.
- Help generate data analysis, and interpret large single-cell genomics data relating to the Human Cell Atlas research generated by the group, shared by collaborators and/or publicly available, including multi-omic and spatial datasets (e.g. scRNAseq, scATAC, 10x Genomics Visium and Xenium).
- To support the implementation innovative and creative data analysis strategies to aid in pursuit of biological insights and clinical translation using single cell research.
- Work in a team to answer research questions formulated together with the members of Haniffa Lab, and with team members across the wider Institute as appropriate.
- Feedback results to project leaders when required to achieve deadlines.
- To prepare high quality data reports and manuscripts to communicate results, including through publication and presentations at scientific meetings.
- To take a full part in the general duties of the team, and to pass on skills and knowledge to other team members and visitors. To take part in wider Sanger Institute activities as appropriate.

**About You**:
You are a bioinformatician with experience analysing genomic data and interpreting biological data. You are seeking a role that includes elements of statistical analysis, data analysis and pipeline engineering. You are a highly detail-oriented problem solver and are eager to learn and develop in the areas in which you have less experience. Teamwork and collaboration are essential aspects of this role, and you will be enthusiastic about creating effective and productive working relationships with collaborators both within and outside the organisation.

**Essential Skills**:

- Masters in relevant quantitative discipline (e.g. Computational Biology, Genetics, Bioinformatics, Physics, Engineering or Applied Statistics/Mathematics); or equivalent working experience in Bioinformatics or a related discipline
- Experience programming in high level scripting languages (Preferably Python and/or R), and the Unix Shell
- Understanding and some experience in the fields of genomics, data processing and high-throughput data analysis
- Experience in single cell genomics data analysis and integration, e.g. scRNAseq, scATAC (desirable)
- Experience in a research environment with an established track record of productivity through publications, or writing reports in industry
- Enthusiastic, proactive attitude and desire to learn
- Strong communication skills to allow efficient interactions with team members
- Commitment, problem-solving skills and attention to detail
- Ability to organise own workload and manage competing priorities
- Ability to summarise complex information and present to a wide variety of audiences in a concise and logical manner
- Demonstrates inclusivity and respect for all

**Other Information**:
**Salary per annum: £35,849-£42,589 (dependent upon skills and experience)**

**Application Process**:
**Closing Date: 28th August 2023**

**Working at Wellcome Sanger**:
Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

**Our Benefits**:
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.