Associate Principal Scientist

6 months ago

Macclesfield, United Kingdom AstraZeneca Full time

Location: Macclesfield, UK (Hybrid - 3 days on site)

AstraZeneca is a global, innovation-driven biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to our patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity.

**The Role**

As a scientific leader (Associate Principal Scientist) specialising in developing kinetic and mechanistic understanding for continuous chemical transformations you will be working in a group dedicated to identifying, developing and delivering continuous manufacturing opportunities in the manufacture of active pharmaceutical ingredients (APIs). The role involves working collaboratively with chemists, engineers, analysts, specialists in instrument automation and control, physical organic scientists, data scientists and others. In the role you will:

- Provide kinetic and reaction mechanistic expertise in the development and implementation of new continuous processes to achieve robust and sustainable manufacturing for the delivery of drug substances. This will include both laboratory experimentation and in-silico modelling.
- Collaborate with AZ scientists or third-party organisations in the development and optimisation of continuous manufacturing processes for new Active pharmaceutical ingredients, with consideration of the requirements of speed, quality, cost, sustainability, reproducibility and efficiency.
- Drive new ways of working, in collaboration with technology experts, to focus on data driven experimentation which will enable AZ’s modelling and simulation aspirations.
- Support problem solving when development or manufacturing issues arise.
- Contribute to the development and delivery of the continuous manufacturing strategy for AZ through collaboration with other leaders in the Continuous group.
- Provide mentorship and coaching to AZ colleagues to help with their long-term development.

**Essential Requirements**
- BSc/MSc/ PhD in Chemistry or relevant experience to an equivalent level.
- Demonstrated experience in the practical development of continuous organic chemistry processes
- A good understanding of synthetic methodologies, reaction mechanisms and modern analytical techniques
- Good collaborative skills to enable effective working with different skillsets.
- Strong communication and influencing skills.

**Desirable Requirements**:

- PhD in mechanistic chemistry or equivalent industrial experience.
- Lab-based pharmaceutical industry and/or process development experience, using a broad range of practical techniques.
- Experience in using a wide variety of off-line analytical techniques and be able to identify and implement more specialist (in-line) approaches when required by liaising with analytical experts.
- Proven record of innovation through, for instance, authorship of papers, inventor status on patents, or presenting at external conferences.
- The ability to develop and analyse multiple solutions to problems.
- Experience mentoring and driving performance and development of your peers.
- Experience in scaling up manufacturing processes from lab to pilot plant.

**Skills and capabilities**
- Ability to challenge, innovate, think critically and flexibly, bringing new solutions and opportunities for chemical development.
- Ability to analyse and interpret complex problems and provide solutions with a high attention to detail.
- Excellent communication skills, with the ability to communicate across interfaces of scientific disciplines, culture, and expertise both internally and externally.
- The ability to confidently participate in, and potentially lead, improvement projects.

  • Associate Principal Scientist

    8 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    **Associate Principal Scientist - Process Analytical technology** **Location - Macclesfield, UK** Join our team as an Associate Principal Scientist for Process Analytical Technology (PAT) and make a significant impact in the development and manufacture of Active Pharmaceutical Ingredients (APIs). As a specialist in PAT for New Modalities, you will drive...

  • Associate Principal Scientist for Pat

    8 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    **Associate Principal Scientist for PAT (New Modalities)** Join our team as an Associate Principal Scientist for Process Analytical Technology (PAT) and make a significant impact in the development and manufacture of Active Pharmaceutical Ingredients (APIs). As a specialist in PAT for New Modalities, you will drive technical excellence amongst our...

  • Associate Principal Scientist

    8 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    **Make a meaningful impact on people’s lives with life-changing medicines** Join the team where everyone feels a personal connection to the people that we impact. From our science labs to manufacturing at scale, we are committed to delivering at the highest quality. It’s inspiring and rewarding work, influencing the product lifecycle to deliver...

  • Associate Principal Scientist

    7 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    **Associate Principal Scientist (Analytical) Senior Project and Technical Lead** AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceutical and the supply of healthcare services. But we’re more than one of the world’s leading pharmaceutical companies. At...

  • Associate Principal Scientist

    6 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    Join us at AstraZeneca, where we put patients first and strive to meet their unmet needs worldwide. We are looking for an Associate Principal Scientist to join our **Technical Operations Science & Innovation (TOSI)** team which is part of the Pharmaceutical Technology & Development (PT&D) organisation. This is your chance to make a meaningful impact on...

  • Associate Principal Data Scientist

    6 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    Description The successful candidate will have a strong background in machine learning (ML) and AI, including neural networks and deep learning. Experience with natural language processing (NLP) and language models including large language models (LLMs) is of particular interest You will be responsible for developing cutting-edge algorithms and models...

  • Senior Scientist

    2 months ago

    Macclesfield, United Kingdom CV-Library Full time

    About Us We are recruiting for a world-leading Contract Research Organisation (CRO) specializing in integrated drug discovery. With a team of over 1,000 professionals, including 900 scientists, partners with major pharma, biotech, and nonprofit organisations worldwide. Since 2004, they have contributed to the development of over 40 pre-clinical and 22...

  • Senior Scientist

    2 months ago

    Macclesfield, United Kingdom CV-Library Full time

    We are currently seeking a bright and experienced Senior Scientist to join our client's dynamic Translational Oncology Department due to significant business growth. This role is essential for supporting all in vivo aspects of drug discovery projects using specialized oncology disease models. About the Role: As a Senior Scientist, you will plan,...

  • Principal Oncology Drug Discovery Specialist

    3 weeks ago

    Macclesfield, Cheshire East, United Kingdom S3 Science Full time

    About S3 ScienceWe are a leading Contract Research Organisation (CRO) with expertise in integrated drug discovery. Our team of over 1,000 professionals, including 900 scientists, partners with major pharma, biotech, and nonprofit organisations worldwide.Job SummaryThis is an exciting opportunity to join our team as a Principal Oncology Drug Discovery...

  • Associate Principle She Scientist

    6 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    Associate Principle SHE Scientist - GSHE Dangerous Goods Lead Location: Dublin Ireland, Macclesfield UK and Warsaw Poland Type: Permanent Competitive Salary and Benefits AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of...

  • Associate Principal Packaging Engineer

    6 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    We have an open position for a Packaging Development Associate Principal Engineer based in our Pharmaceutical Technology and Development (PT&D) department. This role will support the entire PT&D portfolio. PT&D is the bridge, which turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing...

  • Associate Director

    6 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    Associate Director - Chemical Development Location - Macclesfield (UK) Are you ready to make a significant impact on the speed, quality, and cost of the AstraZeneca development portfolio? We are seeking an Associate Director/Director Process Chemistry to join our Chemical Development function in Pharmaceutical Technology and Development (PT&D). ...

  • Chemical Development Associate

    1 week ago

    Macclesfield, Cheshire East, United Kingdom VRS-UK Full time

    About the Role:In this role, you will play a crucial part in everyday operations, working closely with a team of scientists. Your primary focus will be on the analysis of pharmaceutical drug products using techniques such as HPLC, dissolution, and Karl Fischer.You will also support method development and validation, equipment calibration and maintenance,...

  • Statistical Science Associate Director

    7 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    Statistical Science Associate Director (Principal level) – Late Oncology Location: Macclesfield, UK Competitive salary and benefits We are open to discussing working part-time (min Do you have expertise in, and passion for, Biostatistics? Would you like to apply your skills to impact the early phases of drug development and regulatory...

  • Scientific Innovation Lead for Translational Therapies

    3 weeks ago

    Macclesfield, Cheshire East, United Kingdom Lifelancer Full time

    Lead Scientist Job Description Maintaining a strong presence at Alderley Park, Medicines Discovery Catapult serves as a national facility that bridges the UK community to accelerate innovative drug discovery. This connection enables the validation of new approaches and drives key talent and expertise across the sector, supporting the UK life sciences...

  • Automation Lead – Technical Operation, Science, and Information

    6 months ago

    Macclesfield, United Kingdom AstraZeneca Full time

    Job Title: Automation Lead – Technical Operations, Science and Innovation (PT&D) Location: Macclesfield- UK ; Gothenburg- Sweden Introduction to role: Are you passionate about automation and eager to apply your expertise in a company that follows the science and turns ideas into life-changing medicines? If so, AstraZeneca might be the one for...

  • Temp - Senior Laboratory Technician (M/F/d)

    6 months ago

    Macclesfield, United Kingdom Avantor Full time

    The Opportunity: - Avantor has an excellent opportunity for Senior Laboratory Technician, to join our site in Macclesfield. Your work location is one of our major customer's sites at Silk Road Business Park (SK10 2NA). This role will be a full-time, 6 month temporary position. Daily you will be working with Scientist and supporting them with kanban and...

  • Finance Assistant

    6 months ago

    Macclesfield, United Kingdom SKA Organisation Full time

    At the SKAO we are coordinating a global effort to deliver one of the largest science facilities on the planet. The SKAO telescopes will be next-generation instruments that will help to answer key questions in astrophysics, drive technological innovation and support human capital development. More than a dozen partner countries and over a thousand...

  • Delivery Technologist

    6 months ago

    Macclesfield, United Kingdom Avantor Full time

    The Opportunity: Avantor is looking for a GMP-focused Delivery Technologist to join the team based in Macclesfield, UK . In this position you’ll take ownership of supporting all of aspects of the GMP warehouse, shipping, and sample dispatch service operations. This role will be a full-time permanent position based at our customer’s site in...