Head of Biologics

3 weeks ago

Edinburgh, United Kingdom Cumulus Oncology Full time

Cumulus Oncology is focused on the creation of a portfolio of oncology companies, striving to address areas of high unmet medical need and building value for our investors. Our mission is to identify exciting opportunities/novel assets at various stages of development, that can be accelerated towards the clinic, or advancing clinical stage assets. The company has an exceptional team, with a wealth of expertise in the oncology sector. With one spin-out company established, a second close to launch and with ambitious plans to create more, we are looking to expand the team to accelerate growth.

This exciting new role requires the provision of biologics expertise to drive forward a new company concept and will cover a wide range of activities.

**Key Responsibilities**

1. Contribute to the identification and evaluation of targets of interest and potential new assets, taking a lead in discussions with academic groups/asset holders to further understand the opportunity.

2. Design and coordinate experiments with partners (collaborators and CROs) to enhance the understanding of the biology of selected targets and commissioning target validation.

4. Working with partners to identify sources of antigens for experimental work and generation of mAbs, ensuring that the targets are in the correct conformation and of high quality.

5. Critically analyse and interpret data from across a range of methods and provide recommendations for follow on experiments to ensure timely project progress and milestones are achieved.

6. Oversee the generation, engineering and cell-line development for mAbs as well as identification and selection of CDMO and where appropriate oversee the transfer of manufacture to a GMP facility

7. Develop time-efficient and cost-effective programs of work for the assets to IND-ready stage and drive progress to go/no go decisions and/or value inflection points within the agreed budget.

8. Identify, evaluate, and select non-clinical study providers and commission and oversee proof-of-principle and IND-enabling studies.

9. Produce a rolling forecast of the quantity of mAbs needed to meet the requirements of the planned non-clinical and quality (assay development, stability etc) work and manage delivery.

10. Produce project and programme status report to support the contractor’s choice and the discussion with the board of directors.

11. Monitor the literature and competitor activity and flag any new information that could impact the programs and/or risks to the senior leadership team.

12. Attend biologics focused or biopartnering conferences to identify new target or innovative technologies that could be interesting for the company, as well as to present new data.

13. Create, organise, chair and lead the scientific advisory board meeting for the Biologics Newco.

**Ideal Requirements**

1. 8yrs+ experience in biologics development in the field of oncology

2. Experience of leading projects for mAbs development from target identification to IND-enabling studies and working with external providers to deliver against the agreed project plan

3. Ability to understand the biology around novel targets as well as designing experiments to test scientific hypotheses

4. Track record of scientific excellence as evidenced by publications, presentations at conferences and/or the establishment of international collaborations

5. Knowledge gained from experience within the biopharma industry of the process development and manufacture of mAbs and the regulatory requirements for both non-clinical and clinical testing for oncology

6. Able to work remotely within an interdisciplinary environment with multiple inputs across different scientific and business areas with a ‘can-do’ approach to problem solving

7. Strong interpersonal communication skills and effective team working with the ability to clearly present scientific data to a variety of audiences/stakeholders

8. Proactive personality with the ability to drive progress with minimum guidance

9. Excellent written and verbal communication skills and ability to use standard software packages including Excel, PowerPoint, and Word

10. Excellent interpersonal and organisational skills and a strong attention to detail

11. Thrives on working in a team environment with a close-knit group of professionals united by a common mission

**If you are interested in the role, we would love to hear from you.**

**Job Type**: Full time

**Salary**: Dependent on experience

**Salary**: £65,000.00-£120,000.00 per year

**Benefits**:

- Work from home

Schedule:

- Monday to Friday

**Experience**:

- biologics development in the field of oncology: 8 years (required)

Work Location: Hybrid remote in Edinburgh, EH2 3BU

  • PhD Studentship: Upscaling Morphing in Biological Structures

    Found in: beBee S GB - 3 weeks ago

    Edinburgh, United Kingdom The University of Edinburgh Full time

    Continuum mechanics approaches have been used to model the mechanical behaviour of biological (and active) systems at length scales that are large enough. For example, when analysed at the micron-scale, biological membranes can be treated as continuum objects that deform regulated by effective properties such as curvature mismatch or active forces. Those...

  • PhD Studentship: Upscaling morphing in biological structures

    Found in: beBee jobs GB - 3 weeks ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    Continuum mechanics approaches have been used to model the mechanical behaviour of biological (and active) systems at length scales that are large enough.For example, when analysed at the micron-scale, biological membranes can be treated as continuum objects that deform regulated by effective properties such as curvature mismatch or active forces. Those...

  • Research Assistant

    Found in: beBee S GB - 3 weeks ago

    Edinburgh, United Kingdom The University of Edinburgh Full time

    Fixed-Term for 12 months. Full time - 35 hours per week. The Opportunity: We are looking for a post-graduate research assistant to study cellular responses to injury and aging spanning in vitro and in vivo work.  The post will be based in the Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh with Professor...

  • Research Data Assistant

    6 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE06 £30,619 - £35,308 Per Annum** **College of Science and Engineering / School of Biological Sciences / Institute of Quantitative Biology / Biochemistry and Biotechnology** **Full time contract (35 hours per week)** **Please note flexible working will be considered including part-time contract (minimum 24.5 hours per week)** **Fixed term (12...

  • Research Associate

    5 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UOE07 - £39,347 - £46,974** **School of Informatics** **Contract Type - Fixed term - 24 Months** **Full Time - 35 Hours Per Week **The Opportunity**: We are looking for a postdoctoral researcher to join the Biomolecular Control Group at the University of Edinburgh. The group develops computational methods for the design of molecular systems for...

  • Postdoctoral Research Associate

    6 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07 £37,099 to £44,263 per annum (A revised salary range for this grade of £39,347 to £46,974 is planned to take effect from Spring 2024)** **College of Science and Engineering / School of Biological Sciences** **Institute of Quantitative Biology, Biochemistry and Biotechnology & Institute of Molecular Plant Sciences** **Full Time contract: 35...

  • Student Experience Administrator

    3 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE05: £25,285 - £28,929 per annum** **College of Science and Engineering / School of Biological Sciences / Biology Teaching Organisation** **Full time contract: 35 hours per week** **Fixed term contract: end date 29 February 2024 We are looking for a Student Experience Administrator to support the School’s student experience activities. Working...

  • Postdoctoral Research Associate

    Found in: beBee S GB - 3 weeks ago

    Edinburgh, United Kingdom The University of Edinburgh Full time

    Fixed Term Contract until 13th February 2026 (with the possibility of extending for a further 4 months). Full Time – 35 hours per week. We are looking for a Postdoctoral Research Associate in algal synthetic biology to modify photosynthesis through engineering the algal chloroplast genome. The Opportunity: A Postdoctoral Research Associate position in...

  • Research Assistant

    6 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **Grade UE06: £31,396 - £36,024 per annum pro rata **(A revised salary range for this grade of £32,982 to £38,205 is planned to take effect from Spring 2024) **College of Science and Engineering / School of Biological Sciences / Institute of Infection and Immunology Research** **Part-time: 17.5 hours per week** **Fixed-term: for 32 months We are...

  • Deputy Head of Space

    6 days ago

    Edinburgh, United Kingdom Department of International Trade Full time

    The UK’s space sector is critical to delivering over £350bn of services across the economy reliant on Space and space-based services. Space continues to increase in importance to the UK’s economy and national security, with exports and inward investment playing a key role in this. This role of Deputy Head of Space offers an opportunity in one of the...

  • Research Fellow

    2 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07: £35,333.00 - £42,155.00 Per Annum** **Clinical Sciences/Centre for Regenerative Medicine** **Open Ended: Permanent - Full Time: 35 Hours Per Week.** The Opportunity: Do you want to conduct research in computational and systems biology, embedded in one of two world-leading research centres? Do you want to help build algorithms and mathematical...

  • Head Teacher

    Found in: Talent UK 2 C2 - 2 days ago

    Edinburgh, United Kingdom City of Edinburgh Council Full time

    Job Description Children, Education & Justice Services Head Teacher Broughton High School Salary: £, Subject to Job Sizing Hours: 35 per week Broughton High School is a large well-equipped modern PPP school located in the Inverleith/Stockbridge area of North Edinburgh. The school provides co-educational, non-denominational comprehensive education...

  • Head of HR

    3 days ago

    Edinburgh, United Kingdom Registers of Scotland Full time

    **Details**: **Reference number**: - 252223**Salary**: - £52,359 - £65,103- Plus membership of the Civil Service Pension scheme**Job grade**: - Grade 7- C1**Contract type**: - Permanent**Business area**: - RoS - Corporate - People & Change**Type of role**: - Human Resources**Working pattern**: - Full-time**Number of jobs available**: -...

  • Head of Teaching Administration

    3 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **Grade: UE07 - £39,347 - £46,974** **College of Arts, Humanities and Social Sciences** **The School of Philosophy, Psychology & Language Sciences** **Full-time - 35 Hours Per Week** **Contract Type - Open-ended (permanent)** **1 position available The School of Philosophy, Psychology and Language Sciences is seeking a full time Head of Teaching...

  • PhD Studentship: Microfluidic devices for fast diagnosis

    Found in: beBee jobs GB - 3 days ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    Microfluidic devices can achieve high sensitivity and receive results rapidly in diseases diagnosis. As one example of their broad applications, microfluidic devices have the potential in rapid identification of bacteria in patients' biological samples. This can help physicians prescribe appropriate antibiotics quickly, enabling improved treatment and...

  • Head of Teaching Administration

    Found in: beBee jobs GB - 3 weeks ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    The School of Philosophy, Psychology and Language Sciences is seeking a full time Head of Teaching Administration on an open-ended basis. The Opportunity:As a key leader within our Professional Services group, the successful applicant will lead on the teaching administration service providing a robust and responsive support to academics and students,...

  • Head of Teaching Administration

    Found in: beBee S GB - 3 weeks ago

    Edinburgh, United Kingdom The University of Edinburgh Full time

    The School of Philosophy, Psychology and Language Sciences is seeking a full time Head of Teaching Administration on an open-ended basis.  The Opportunity: As a key leader within our Professional Services group, the successful applicant will lead on the teaching administration service providing a robust and responsive support to academics and students,...

  • Head of Reporting

    6 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE08: £44,414.00 - £52,841.00 Per Annum** **Corporate Services Group, Data Driven Innovation Programme Office** **Open Ended Contract - Permanent: Full Time - 35 Hours per Week** The University of Edinburgh is seeking an experienced and forward-thinking Head of Reporting to lead the monitoring, evaluation, benefits realisation, and impact assessment...

  • Depute Head Teacher

    Found in: Talent UK 2 C2 - 2 days ago

    Edinburgh, United Kingdom City of Edinburgh Council Full time

    Job Description CF: Children and Education Justice Services Depute Headteacher St Francis RC Primary School Salary: £63, per year Hours: 35 per week St Francis RC Primary School is a growing denominational Catholic school located in the East of the City in the great Craigmillar area. Our school was created in and moved into the current joint campus...

  • Head of Centre

    Found in: Talent UK 2 C2 - 2 weeks ago

    Edinburgh, United Kingdom City of Edinburgh Council Full time

    Job Description Children, Education and Justice Services Head of Centre - Fixed term until 11/8/ Forest Kindergarten Salary: £42, - £50, per year Hours: 36 per week These posts will support approx. 5 forest kindergarten sites across the city. A key aspect for this role will be to support the ethos of outdoor learning and promote the benefits that...