Functionalized Nanoparticles for Experimental

3 weeks ago


Birmingham, United Kingdom Aston University Full time

**Functionalized nanoparticles for experimental colorectal cancer therapy**

**Department**:College of Health and Life Sciences

**Contract Type**:Fixed Term

**Basis**:Full Time

**Closing Date**:30th June 2023 [23:59 GMT]

**Supervisory Team**:
Principal supervisor: Dr Boris Kysela

Associate supervisors: Dr Theo Kantidakis

Dr Deepak Singh-Ranger (clinical)

Applications are invited for a three-year Postgraduate studentship, supported by the College of Health and Life Sciences, at Aston University.

**The position is available to start in October 2023**

**Financial Support**

This studentship includes a fee bursary to cover the home/EU fees rate, plus a maintenance allowance of £18,622 in 2023/4.

**Overseas Applicants**

**Background to the Project**

Colon cancer is one of the most frequently diagnosed malignancies representing 11% of all new cases of cancer worldwide in adults and is the third largest cause of cancer deaths. The standard therapy comprises of surgery combined with chemotherapy. Since 1957, the most common drug in the treatment of colon cancer is 5-Fluorouracil (5-FU), a heterocyclic aromatic compound (an analogue of uracil), that interferes with the metabolism of nucleosides and, when incorporated into DNA and RNA, leads to cytotoxicity and cell death. Nevertheless, the overall response rate for the advanced colorectal cancer to 5-FU alone is only 10-15% and even in combination with other anti-tumour (mostly cis-Pt derivatives), less than a half of the tumours respond to the therapy, due to rapid development of drug resistance. Therefore, new strategies for therapy and resistance reversal are urgently needed. Our group have already developed several new designs of functionalized precious metal nanoparticles with a potential to increase the dose efficacy of therapeutic DNA damaging agents by attenuating genome stability maintenance mechanisms in targeted cells. The main objective of this project will be development of functionalized nano constructs for targeting the most important DNA repair pathways for resistance development and treatment efficiency of chemotherapeutics used in colon cancer treatment.

**Person Specification**

**Contact information**
- A copy of your current CV
- Copies of your academic qualifications for your Bachelor degree, and Masters degree (if studied); this should include both certificates and transcripts, and must be translated in to English
- A research proposal statement*
- A personal statement
- Two academic references
- Proof of your English Language proficiency

**Please include the supervisor’s name, project title and project reference in your Personal Statement.



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