Research Fellow

1 month ago

London, United Kingdom University College London Full time

**Ref Number**

B02-06820

**Professional Expertise**

Research and Research Support

**Department**

School of Life & Medical Sciences (B02)

**Location**

London

**Working Pattern**

Full time

**Salary**

£42,099-£50,585

**Contract Type**

Permanent

**Working Type**

On site

**Available For Secondment**

No

**Closing Date**

16-May-2024

**About us**:
The Department of Neurodegenerative Disease is recognised as internationally leading in the study of neurodegenerative diseases causing dementia and related disorders. The Department has a strong focus on mechanistic dissection of genetic, molecular cellular and neuropathological processes which underlie neurodegeneration in particular diseases and across the neurodegeneration spectrum.

The UCL Huntington’s Disease Centre, based in the Department, is uniquely placed world-wide to translate mechanistic insights to ‘first in human’ studies. Our research combines sophisticated cell-based systems with rigorously standardised preclinical target validation to prime mechanistically driven drug development initiatives. The Centre integrates clinical and laboratory work with small proof-of-concept first in human studies in patients in the Leonard Wolfson Experimental Neurology Centre (LWENC) prior to initiating larger phase 2 and 3 clinical trials including novel huntingtin-lowering trials.

**About the role**:
We have an exciting opportunity for a Research Fellow to join this world-leading Centre to investigate the role of the DNA damage response (DDR) in Huntington’s disease pathogenesis. You will examine the involvement of DDR proteins in repeat expansion in patient-derived cell models and will use induced pluripotent stem cells (iPSCs) from patients with HD to study the role of DDR proteins, focusing on the MutL MMR complexes, in repeat instability.

The role is available from 01 September 2024 and is funded by research grant funding until 31 August 2026 in the first instance.

A full job description and person specification for this role can be accessed below.

**About you**:
You will hold an Honours degree and a PhD (or equivalent) in a relevant biological or related field. You should possess extensive experience in experimental laboratory research, along with experience in iPSC cultures and molecular biology, including PCR assays and transduction/transfection of cells.

Excellent oral and written communication skills, and good interpersonal skills with the ability to work co-operatively in a multidisciplinary setting are also required. Experience of DNA repair or cancer DNA biology and an understanding of neuroscience and neurodegenerative diseases are desirable.

**What we offer**:
Appointment as Research Fellow is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be as Research Assistant (salary £37,332 - £39,980 per annum) with appointment as Research Fellow being backdated to the date of final submission of the PhD thesis.

As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:

- 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
- Additional 5 days’ annual leave purchase scheme
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- Immigration loan
- Relocation scheme for certain posts
- On-site nursery
- On-site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
- Discounted medical insurance

**Our commitment to Equality, Diversity and Inclusion**:
The Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our EDI website for more information about our initiatives and priorities. The Institute also holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality.

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.

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