Research Associate

1 month ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Research Assistant Salary**: £29,619 - £31,411 per annum

**Research Associate Salary**: £32,348 - £34,308 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 14 February 2023

The Role

This post holder is to take ownership and deliver this proposed and exciting research project within the time limits specified by the JGWP project grant (1 year). The post holder will receive supervision and support from 3 principal investigators based at the Newcastle University Centre for Cancer and have access to the full suite of infrastructure required to successfully complete this project. The post holder will work in the vibrant and stimulating research environment at the Wolfson Childhood Cancer Research Centre. Attendance and presentation of research progress at inter / -national conferences will be strongly encouraged.

The project consists of the following work package. Explore and determine potential molecular mechanisms underlying the observed drug synergy between Dasatinib and Dexamethasone in leukaemia (PMID: 32139432). This analysis might include chromatin and RNA immunoprecipitation, CRISPR knock-out and knock-in cell lines using bespoke PCR-based HDR donor templates, development of APEX2-/TurboID peroxidase-directed proximal biotinylation assays to define target protein interactomes, and the use of R to analyse proteomics data-sets and SUPPA2 for global splicing analysis.

For more information about us please visit here.

This post is full time and fixed term until 29 February 2024 (12 months)

Key Accountabilities
- Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
- Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
- Determine appropriate methodologies for research, with advice and support where required
- Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
- Assess research findings for the need/scope for further investigations
- Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
- Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
- May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
- Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
- May contribute to events celebrating the public engagement of science/social sciences/humanities
- Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment

The Person (Essential)

Knowledge, Skills and Experience
- Ability to work well as part of a team and rapidly acquire new skills
- Likelihood of advanced skills directly related to the research projects
- High level of analytical and problem-solving capability
- Ability to communicate complex information with clarity and to encourage the commitment of others
- Experience of research with clear transferable skills and some experience or awareness of the research environment
- Presentations at conferences and/or high-quality publications
- Experience in cancer studies
- Sound knowledge of contemporary molecular and cellular techniques (e.g. IB, IP, IF, qRT-PCR)
- Specific expertise in chromatin and RNA immunoprecipitation, CRISPR knock-out and knock-in, APEX2-/TurboID peroxidase-directed proximal biotinylation assays to define target protein interactomes, and minigene splicing assays
- Considerable expertise in using R to analyse large RNA sequencing and proteomics data-sets; experience of SUPPA2 for global splicing analysis

Desirable
- Transcriptomics
- High dimensional data analysis
- Knowledge of other bio-informatic packages

Attributes and Behaviour
- Enthusiastic, team player, motivated, good communicator
- Diligent, organised, ability to work independently, analytical skills

Desirable
- Writing and presentation skills

**Qualifications**:

- PhD in molecular biology

Newcastle is an inclusive global University community where everyone is treated with dignity and respect. As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people

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