Genomics Specialist LMS 2157

3 months ago

London, United Kingdom Medical Research Council Full time

The LMS Genomics Lab provides access and support to state-of

The Genomics Lab supports translational research through it’s following services:

- DNA/RNA QC and library preparation
- Short read and long read NGS sequencing - MiSeq, NextSeq2000, and ONT (PromethIon + MinION)
- 10X Genomics single cell and Visium spatial transcriptomics
- Nanostring spatial biology - GeoMx

You will be joining us at an exciting time as we continue to expand our genomics portfolio to include spatial transcriptomics capabilities, and continue to develop our utilisation and innovation of sequencing technologies, library preparation methods, and single cell techniques.

**Main Responsibilities**:

- Laboratory experiments - NGS library preparation, single-cell sample preparation, operating Illumina sequencers and other specialised instruments, data analysis and Bioinformatics QC, design and perform spatial genomics experiments involving histology and imaging techniques
- Support and train researchers for experimental design, sample QC, data generation and QC, troubleshooting, interacting with users to discuss results
- Liaising with various stakeholders including specialist vendors engineers and technical teams, peers technical specialists across London and the UK, presenting data to researchers both within the LMS and at national meetings
- Participate in scientific discussions and be responsible for initiating and conducting collaborative research projects involving new spatial transcriptomics modalities
- Report scientific results in a publication quality format and present work at national meetings
- Be actively involved in the development of new genomics, single-cell and spatial genomics approaches to support the scientific programmes of the LMS

Person Specification
- Essential:_
- MSc in Genetics, Molecular Biology or closely related discipline
- Excellent working knowledge of molecular biology techniques working with RNA and DNA
- Excellent working knowledge of NGS sequencing and single-cell technologies e.g. Illumina NGS and 10X Genomics
- Good understanding of Bioinformatics concepts applied to genomics data analysis
- Desirable: _
- Professional Registration with a relevant body at Chartered Scientist CSci or Registered Scientist RSci
- Essential: _
- Extensive experience in advising, training and supporting users, troubleshooting complex problems, communicating with researchers at all level of seniority and knowledge
- Working experience in Bioinformatics applied to NGS and single-cell data QC and analysis including FastQC, FastqScreen, IGV genome analysis,10X Cell Ranger
- Excellent written and oral communications skills including the ability to present complex data to a scientific audience
- Confident in engaging is scientific discussion, establishing collaborative projects and present results to a scientific audience
- Desirable: _
- Previous experience in histology and imaging techniques applied to spatial biology would be an advantage e.g. Nanostring GeoMx, 10X Visium, Resolve Biosciences, Parse Biosciences and ScaleBiosciences
- Previous experience with long-read sequencing technologies like Nanopore or PacBio would be an advantage

**Personal skills / behaviours / qualities (will be assessed at interview)**:

- Essential: _
- Outstanding attention to detail and confident ability to work with precious and rare samples
- Outstanding organisational skills and excellent prioritisation and time management
- Ability to work under pressure and against tight deadlines, across multiple projects
- Proactive and enthusiastic person with strong commitment and motivation to the job and to the success of the Facility and the Institute
- Confident communicator with experience in dealing with sensitive issues
- Strong will and ability to learn and develop new techniques and skills in a proactive manner
- Collaborative attitude: ability and will to proactively work collaboratively with LMS and external researchers
- This post may require some out-of-hours working and travel to national seminars/meetings
- Flexibility in working hours to allow for collaborative work and to provide the best support within the constraints of a small team
- Strong interest and initiative in researching and learning about emerging technologies, through reading scientific publications, attending seminars, conferences and transferring knowledge into facility work
- Ability and willingness to train others and engage in sharing of knowledge

Further Information
- Please
- **LMS 2157**

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Ch

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