Oligonucleotide Production Scientist

3 weeks ago


Oxford, United Kingdom Oxford Nanopore Technologies Full time

Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and a commercial presence in many global locations across the US, APAC and Europe.
Oxford Nanopore's sequencing platform is the only technology that offers real-time analysis, in fully scalable formats from pocket to population scale, that can analyse native DNA or RNA and sequence any length of fragment to achieve short to ultra-long readlengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere
We are seeking a highly motivated individual to join as Oligonucleotide Scientist supporting the purification and manufacturing of highly complex oligonucleotides.
The Details...
This is an exciting and challenging role as part of the newly established Oligonucleotide Production facility based at the Harwell Campus site. The oligonucleotide production team will produce a range of high-quality, complex oligonucleotide standards to supportour Sequencing Kit product range. Collaboration, innovation and quality are at the forefront of our team's vision as we grow the facility to support the rapid expansion of the product range.
A day in this role might include:

- Purification of complex oligonucleotides.
- Running HPLC, CE and LC-MS analytical methods for in-process and end-point monitoring of quality.
- Carrying out low cross-contamination workflows needed to handle multiplexing oligonucleotide samples.
- Oligonucleotide conjugation procedures and SPE clean-up protocols.
- Assisting to develop effective quality systems in line with ISO standards.
- Upkeep of laboratory space including the maintenance of analytical instrumentation.
- Ensuring a safe working environment for all team members and a culture of continuous improvement for health & safety.
- Ensuring the smooth transfer of new purification methods from Development into Production
- Preparing clearly articulated experimental reports and maintaining well-organised records.
- Working and communicating effectively with other groups in Manufacturing, Supply Chain, Procurement, Development and external suppliers.
- Time to focus on career development and building connections within the company
What We're Looking For...
- A clear and consistent focus on the highest safety standards.
- Experience in a relevant industrial production environment including following and writing standard operating procedures.
- Experience working in a GxP regulatory laboratory would be advantageous.
- Good working knowledge of oligonucleotide analytical and preparative techniques, in particular HPLC.
- Strong problem solving and analytical skills.
- Excellent collaborative, interpersonal and communication skills.
- Organisation skills and attention to detail will be essential.
Training will be given and, as such, a willingness to learn and develop is required.
Applications are encouraged from highly motivated individuals who enjoy taking on new challenges, are quickly adaptable in an exciting and fast-paced environment, and who perform well under pressure.
We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of whichmake for a wonderful working environment.
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