Research Fellow

4 weeks ago

London, United Kingdom University College London Full time

**Ref Number**

B02-04803

**Professional Expertise**

Research and Research Support

**Department**

School of Life & Medical Sciences (B02)

**Location**

London

**Working Pattern**

Full time

**Salary**

See advert text

**Contract Type**

Permanent

**Working Type**

On site (> 80% of working time)

**Available For Secondment**

No

**Closing Date**

12-Apr-2023

**About us**:
The Research Department of Neurodegenerative Disease focuses on the study of neurodegenerative diseases causing dementia and related disorders. The Department has a strong focus on mechanistic dissection of genetic, molecular, cellular and neuropathological processes which underlie neurodegeneration in particular diseases and across the neurodegeneration spectrum. A related touchstone of our research is to identify pathophysiological mechanisms and markers that link molecular pathology to clinical phenotypes of neurodegenerative disease.

The Isaacs Lab investigates the molecular mechanisms underlying frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We are particularly interested in the C9orf72 gene, which is a common cause of both FTD and ALS and the CHMP2B gene, which is a rare cause of FTD. We are working to translate our research findings into potential therapies using gene therapy and high-throughput screening approaches.

The Carlton Lab investigate membrane trafficking and organelle remodelling in dividing and non-dividing cells. We have a particular interest in the family of ESCRT proteins, which play important roles in endosomal sorting, nuclear envelope repair and regeneration, cytokinesis and membrane repair. We use a combination of biochemistry, high-resolution imaging and molecular biology to unpick the basic functions of these proteins. Whilst a King’s College London group, the Carlton lab is based at the Francis Crick Institute, allowing access to both King’s
- and Crick-based training, development opportunities and research platforms.

**About the role**:
We are looking for a Research Fellow to join a project funded by an exciting collaborative grant between the Isaacs and Carlton Labs, allowing access to a range of different experimental approaches and techniques.

You will perform CRISPR screens in iPSC-derived neurons and microglia to identify new factors required for membrane repair at both plasma and endolysosomal membranes.

The post is available from 01 April 2023 and is funded by the Chan Zuckerberg Initiative until 31 July 2026 in the first instance.

A full job description and person specification for this role can be accessed below.

**About you**:
You will have, or be about to obtain, a PhD in a relevant discipline (e.g., biomedical research) and experience with iPSC culture and differentiation. Experience with CRISPR approaches, with confocal imaging and analysis, and with molecular biology techniques such as cloning, lentiviral transduction, and qPCR is essential.

**What we offer**:
The role is offered with salary in the range of £38,308 - £43,745 per annum including London Allowance.

Appointment as Research Fellow is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be as Research Assistant (salary £34,502- £36,348 per annum) with appointment as Research Fellow being backdated to the date of final submission of the PhD thesis.

As well as the exciting opportunities this role presents, we also offer great benefits, some of which are below:

- 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
- Additional 5 days’ annual leave purchase scheme
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- Immigration loan
- Relocation scheme for certain posts
- On-Site nursery
- On-site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
- Discounted medical insurance

**Our commitment to Equality, Diversity and Inclusion**:
The Institute prides itself on operating in an all-inclusive environment irrespective of personal, physical, or social characteristics. Teamwork is highly valued, individual strengths are recognised and celebrated, and we are committed to advancing the careers of everyone. 12% of Institute staff are actively working on Equality, Diversity and Inclusion (EDI) initiatives; visit our EDI website for more information about our initiatives and priorities. The Institute also holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality.

As London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.

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