Research Fellow

2 weeks ago

London, United Kingdom University College London Full time

**Ref Number**

B02-06074

**Professional Expertise**

Research and Research Support

**Department**

School of Life & Medical Sciences (B02)

**Location**

London

**Working Pattern**

Full time

**Salary**

See advert text

**Contract Type**

Fixed-term

**Working Type**

Hybrid (20% - 80% on site)

**Available For Secondment**

No

**Closing Date**

09-Apr-2024

**About us**:
**About the role**:
Applicants are invited for a 3-year post-doctorate research project funded by Children with Cancer UK. In this project you will work at the UCL Great Ormond Street Institute of Child Health under supervision of Prof Owen Williams. The aims of this project are to evaluate the efficacy of novel therapies and clinically relevant agents using Acute Myeloid Leukaemia (AML) patient-derived xenograft models in vitro and in vivo, to identify genes and pathways whose disruption sensitises AML cells to novel therapeutics, and to determine mechanisms governing resistance and increased sensitivity to transcription factor perturbation in AML cells. This project is based on our published research identifying potent anti-AML activity of mebendazole, through targeting the transcription factor c-MYB for proteasomal degradation (Walf-Vorderwülbecke et al, 2018 Leukemia 32:882). The project will involve lentiviral CRISPR drop-out screens and leukaemia co-culture models. Through this research we aim to identify novel therapies that will eventually improve the outcomes of children diagnosed with this aggressive disease. The salary offered in this role is £40,524 - £43,847 per annum and is funded for 3 years in the first instance.

**About you**:
Experience in tissue culture and molecular biology is essential, and experience with in vitro and in vivo cancer assays is an advantage. Applicants must have (or at least submitted) a PhD in experimental biology. Previous experience with a productive track record in the cancer biology research field is strongly recommended. Individuals without such experience, but with an exceptional track record in productive research in related areas, are also encouraged to apply.

**What we offer**:
As well as the exciting opportunities this role presents we also offer some great benefits some of which are below: 41 Days holiday (including 27 days annual leave 8 bank holiday and 6 closure days) Defined benefit career average revalued earnings pension scheme (CARE) Cycle to work scheme and season ticket loan On-Site nursery On-site gym Enhanced maternity, paternity and adoption pay Employee assistance programme: Staff Support Service Discounted medical insurance

**Our commitment to Equality, Diversity and Inclusion**:

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