Senior Scientist, Research and Development

4 weeks ago

Slough Berkshire, United Kingdom Energy Jobline CVL Full time

Are you an experienced Senior Scientist? Do you have experience in recombinant protein production?
We are recruiting for a Senior Scientist to work within our clients Protein Production Group supporting projects from early stage target validation through to those undergoing pre-clinical evaluation, by generating recombinant protein reagents for immunisation, structural studies, assays and compound screening. All reagents produced undergo biophysical analysis in order to enhance our clients understanding of their stability and solubility.
You will play a key role in project success by generating high quality protein reagents in a timely manner, as well as assisting with antibody discovery. The successful candidate will have the opportunity to rapidly impact on a wide range of our clients projects, and to significantly contribute to the progression of these projects into the clinic and beyond.
This role is offered on a full time 12 month contract basis initially.
Responsibilities:
You will be responsible for expressing and purifying high-quality recombinant protein reagents to support UCB's novel world-leading antibody and NCE drug discovery platforms for a variety of exciting therapeutic projects.
You will have an excellent and proven track record of protein reagent delivery.
You will use your excellent practical skills, communication and team working abilities to drive innovative projects forward from the laboratory.
You will be responsible for clearly presenting work and engaging in discussion in a variety of cross-functional and external collaborator meetings.Qualifications / Experience:
Candidates will have extensive experience (PhD holder or graduate with 4-5 years) in protein biochemistry, focusing on recombinant protein production, preferably in an industrial environment
We are looking for candidates who are fully independent and competent in the following skill sets:
Molecular Biology (DNA manipulation techniques and comprehensive knowledge and experience with software used in manipulating protein and DNA sequences (VNTI) and molecular visualisation of proteins (PyMOL or similar).
Proficient in E.coli, insect and mammalian cell expression systems (and experience in 15N, 13C and 2H labelled expression in E.coli)
Fully independent in protein purification techniques (affinity, ion exchange, hydrophobic interaction chromatography, size exclusion chromatography, analytical SEC, UV-Vis spectroscopy, and protein refolding techniques) and extensive experience working with AKTA purification platforms and associated software.
Fully competent in protein characterisation techniques: SDS-PAGE, Western blot, analytical SEC, UV-Vis spectroscopy and UPLC.
Excellent biochemistry knowledge with hands on experience of protein labelling and characterisation.
Good understanding of recombinant protein expression systems and the molecular biology involved in generating expression constructs.
Thorough knowledge of the latest technologies involved in protein purification.
Track record of recombinant protein production covering multiple protein classes including enzymes, structural proteins, cell signalling factors, cell surface receptors and their ligands produced as intracellular and secreted proteins.
A scientist with an inquisitive and innovative nature and a passion for delivering innovative new medicines for patients suffering with serious disease.In 2025, this site will relocate from Slough to Windlesham Surrey
Randstad CPE values and promotes equality. No terminology in this advert is intended to discriminate against any of the protected characteristics that fall under the Equality Act 2010. We encourage and welcome applications from all sections of society and are more than happy to discuss reasonable adjustments and/or additional arrangements as required to support your application.
Candidates must be eligible to live and work in the UK.
For the purposes of the Conduct Regulations 2003, when advertising permanent vacancies we are acting as an Employment Agency, and when advertising temporary/contract vacancies we are acting as an Employment Business #J-18808-Ljbffr

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