Senior/Research Scientist

2 weeks ago

Slough Berkshire, United Kingdom ROYAL SOCIETY OF CHEMISTRY Full time

Job Title: Senior/Research Scientist - Mass spec

Contract: 12 months

Location: Slough

Salary: £28.09 - 33.58 PAYE, £38.24 Umbrella

SRG are working with a Global Biopharmaceutical company to help them find a Senior/Research Scientist to join their busy team. This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group.

Key Responsibilities will include:
  • Structural and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.
  • proven track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.
  • manage and prioritise the demands from multiple projects.


Essential Requirements:
  • PhD or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions.
  • Experienced with Waters data processing software packages (PLGS) and DynamX.
  • Practical knowledge Waters HDX-MS system.
  • Use of structural visualisation tools (PyMOL, Chimera or similar).
  • Experienced with HDX-MS experiments using NBE and NCE molecules.
  • Excellent organisational, communication, record keeping and team-working abilities.


Desirable Requirements:
  • HDX-MS analysis of membrane proteins.
  • Troubleshooting and maintenance of Waters LC/MS equipment.
  • Practical ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
  • Proven track record of publications related to mass spectrometry in peer reviewed journals.
  • Appreciation of recombinant protein expression systems and PTMs.
  • Working knowledge of Thermo Scientific Orbitrap MS systems.



Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy. #J-18808-Ljbffr

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