Research And Development Scientist

2 weeks ago

Slough, United Kingdom SRG Full time

Job Title: Senior/Research Scientist – Mass spec

Contract: 12 months

Location: Slough

Salary: £28.09 – 33.58 PAYE, £38.24 Umbrella


SRG are working with a Global Biopharmaceutical company to help them find a Senior/Research Scientist to join their busy team.


This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group.



Key Responsibilities will include:

  • and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.
  • track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.
  • and prioritise the demands from multiple projects.



Essential Requirements:

  • or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions.
  • with Waters data processing software packages (PLGS) and DynamX™.
  • knowledge Waters HDX-MS system.
  • of structural visualisation tools (PyMOL, Chimera or similar).
  • with HDX-MS experiments using NBE and NCE molecules.
  • organisational, communication, record keeping and team-working abilities.



Desirable Requirements:

  • analysis of membrane proteins.
  • and maintenance of Waters LC/MS equipment.
  • ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
  • track record of publications related to mass spectrometry in peer reviewed journals.
  • of recombinant protein expression systems and PTMs.
  • knowledge of Thermo Scientific Orbitrap MS systems.

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